Department of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Department of Breast Cancer, Cancer Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
J Int Med Res. 2021 Feb;49(2):300060520977417. doi: 10.1177/0300060520977417.
This study was performed to evaluate the association of preoperative anxiety with inflammatory indicators and postoperative complications in patients undergoing scheduled aortic valve replacement surgery.
A prospective cohort study was performed. The Hamilton Anxiety Scale was used to assess preoperative anxiety. The serum white blood cell (WBC) count and concentrations of C-reactive protein, interleukin (IL)-6, and IL-8 were measured 1 day preoperatively and 3 and 7 days postoperatively. Postoperative complications were also recorded.
Seventy-three patients were included. The incidence of preoperative anxiety was 30.1% (22/73). The payment source was the only independent risk factor for preoperative anxiety. The incidence of postoperative complications was lowest in the mild anxiety group. The WBC count 3 days postoperatively was significantly lower in the mild than moderate-severe anxiety group. The IL-8 concentration 1 day preoperatively was highest in the no anxiety group.
Mild preoperative anxiety might help to improve clinical outcomes. However, further investigations with more patients are warranted. Patients with different degrees of anxiety may have different levels of inflammatory cytokines.
本研究旨在评估行择期主动脉瓣置换术患者术前焦虑与炎症指标及术后并发症的关系。
进行前瞻性队列研究。采用汉密尔顿焦虑量表评估术前焦虑。术前 1 天及术后 3 天、7 天检测白细胞计数（WBC）及 C 反应蛋白、白细胞介素（IL）-6、IL-8 浓度。记录术后并发症。
共纳入 73 例患者。术前焦虑发生率为 30.1%（22/73）。付费方式是术前焦虑的唯一独立危险因素。轻度焦虑组术后并发症发生率最低。术后 3 天，WBC 计数在轻度焦虑组显著低于中重度焦虑组。术前 1 天，无焦虑组 IL-8 浓度最高。
轻度术前焦虑可能有助于改善临床结局。但需要更多患者的进一步研究。不同程度焦虑的患者可能具有不同水平的炎症细胞因子。
