De Bruyne Pauline, Ito Shinya
Department of Paediatrics and Medical Genetics, Ghent University, Gent, Belgium.
Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Arch Dis Child. 2018 Jan;103(1):78-82. doi: 10.1136/archdischild-2017-314026.
Proton pump inhibitor (PPI) use is becoming increasingly common. Although the toxicity profiles of PPIs are not well understood particularly in children, PPIs have been associated with increased risks of gastrointestinal and respiratory tract infection, vitamin B deficiency, hypomagnesaemia, bone fractures, and rebound hyperacidity after discontinuation. Prescribers should take into account that PPI uses pose toxicity risks, which remain to be fully characterised in infants and children.
质子泵抑制剂（PPI）的使用正变得越来越普遍。尽管PPI的毒性特征尚未完全明确，尤其是在儿童中，但PPI已与胃肠道和呼吸道感染风险增加、维生素B缺乏、低镁血症、骨折以及停药后反跳性胃酸过多有关。处方者应考虑到PPI的使用存在毒性风险，而这些风险在婴幼儿和儿童中仍有待充分明确。
