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急性丙型肝炎治疗：意大利感染与热带病学会专家小组的建议。

Treatment of acute hepatitis C: recommendations from an expert panel of the Italian Society of Infectious and Tropical Diseases.

机构信息

Infectious Diseases, Campania University "Luigi Vanvitelli", Naples, Italy.

Infectious Diseases, Niguarda Hospital, Milan, Italy.

出版信息

Infection. 2018 Apr;46(2):183-188. doi: 10.1007/s15010-017-1107-z. Epub 2017 Dec 13.

DOI:10.1007/s15010-017-1107-z
PMID:29238918
Abstract

AIM

This paper is aimed at providing practical recommendations for the management of acute hepatitis C (AHC).

METHODS

This is an expert position paper based on the literature revision. Final recommendations were graded by level of evidence and strength of the recommendations.

RESULTS

Treatment of AHC with direct-acting antivirals (DAA) is safe and effective; it overcomes the limitations of INF-based treatments.

CONCLUSIONS

Early treatment with DAA should be offered when available.

摘要

目的

本文旨在为急性丙型肝炎（AHC）的管理提供实用建议。

方法

这是一篇基于文献复习的专家立场文件。最终建议根据证据水平和推荐强度进行分级。

结果

直接作用抗病毒药物（DAA）治疗 AHC 安全有效；它克服了基于 IFN 的治疗方法的局限性。

结论

有条件时应尽早采用 DAA 进行治疗。

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本文引用的文献

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Clin Gastroenterol Hepatol. 2018 Jun;16(6):977-978. doi: 10.1016/j.cgh.2017.10.032. Epub 2017 Nov 28.
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Ledipasvir-sofosbuvir for 6 weeks to treat acute hepatitis C virus genotype 1 or 4 infection in patients with HIV coinfection: an open-label, single-arm trial.6 周 Ledipasvir-索磷布韦治疗 HIV 合并感染的急性丙型肝炎病毒基因型 1 或 4 感染：一项开放标签、单臂试验。
Lancet Gastroenterol Hepatol. 2017 May;2(5):347-353. doi: 10.1016/S2468-1253(17)30003-1. Epub 2017 Mar 1.
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根据升级指南进行的预处理评估和直接抗病毒治疗方案的演变：一项针对HIV/HCV合并感染患者的回顾性研究
Med Sci (Basel). 2018 Sep 20;6(4):81. doi: 10.3390/medsci6040081.
Sofosbuvir Plus Ribavirin Without Interferon for Treatment of Acute Hepatitis C Virus Infection in HIV-1-Infected Individuals: SWIFT-C.
索磷布韦联合利巴韦林无需干扰素治疗HIV-1感染个体的急性丙型肝炎病毒感染：SWIFT-C研究
Clin Infect Dis. 2017 Apr 15;64(8):1035-1042. doi: 10.1093/cid/cix025.
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Lancet Infect Dis. 2017 Feb;17(2):215-222. doi: 10.1016/S1473-3099(16)30408-X. Epub 2016 Oct 28.
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