Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Perelman School of Medicine, Philadelphia, PA, USA.
Histopathology. 2018 Jan;72(1):40-52. doi: 10.1111/his.13348.
This article reviews the small percentage of thyroid tumours that are not classified as classic papillary thyroid carcinoma, follicular thyroid carcinoma, and medullary thyroid carcinoma. It includes subtypes of papillary thyroid carcinoma, including, tall-cell, hobnail/micropapillary, columnar cell, diffuse sclerosing and solid variants. Poorly differentiated carcinoma, high-grade carcinoma and anaplastic thyroid carcinoma are reviewed. Also discussed are entities that are unusual but need to be recognized as primary thyroid neoplasms, i.e. mucoepidermoid carcinoma, sclerosing mucoepidermoid carcinoma with eosinophilia, and mammary analogue secretory carcinoma/secretory carcinoma. The pathological features and prognostic factors are described; a brief review of molecular correlates of these neoplasms is included.
本文回顾了一小部分未被归类为经典的甲状腺乳头状癌、滤泡状甲状腺癌和甲状腺髓样癌的甲状腺肿瘤。它包括甲状腺乳头状癌的亚型，包括高细胞型、鞋钉样/微乳头状型、柱状细胞型、弥漫硬化型和实体型。本文还回顾了低分化癌、高级别癌和间变性甲状腺癌。此外，还讨论了一些不常见但需要被认为是原发性甲状腺肿瘤的实体，即黏液表皮样癌、伴有嗜酸性粒细胞增多的硬化性黏液表皮样癌，以及乳腺样分泌癌/分泌癌。本文描述了这些肿瘤的病理特征和预后因素，并简要回顾了这些肿瘤的分子相关性。
