LINE-1 反转录转座子在健康和患病人类大脑中的分布。
LINE-1 retrotransposons in healthy and diseased human brain.
机构信息
Department of Pediatrics/Rady Children's Hospital San Diego, University of California San Diego, La Jolla, California, 92093.
出版信息
Dev Neurobiol. 2018 May;78(5):434-455. doi: 10.1002/dneu.22567. Epub 2017 Dec 29.
Abstract
Long interspersed element-1 (LINE-1 or L1) is a transposable element with the ability to self-mobilize throughout the human genome. The L1 elements found in the human brain is hypothesized to date back 56 million years ago and has survived evolution, currently accounting for 17% of the human genome. L1 retrotransposition has been theorized to contribute to somatic mosaicism. This review focuses on the presence of L1 in the healthy and diseased human brain, such as in autism spectrum disorders. Throughout this exploration, we will discuss the impact L1 has on neurological disorders that can occur throughout the human lifetime. With this, we hope to better understand the complex role of L1 in the human brain development and its implications to human cognition. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 434-455, 2018.
摘要
长散布元件 1（LINE-1 或 L1）是一种具有自我移动能力的转座元件，能够在人类基因组中移动。据推测，人类大脑中的 L1 元素可以追溯到 5600 万年前，并在进化中幸存下来，目前占人类基因组的 17%。L1 逆转录转座被认为有助于体细胞嵌合体。这篇综述主要关注 L1 在健康和患病的人类大脑中的存在，如在自闭症谱系障碍中。在整个探索过程中，我们将讨论 L1 对人类一生中可能发生的神经紊乱的影响。通过这一点，我们希望更好地理解 L1 在人类大脑发育中的复杂作用及其对人类认知的影响。 © 2017 Wiley Periodicals, Inc. 发育神经生物学 78：434-455，2018 年。
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