Mobile DNA in Health and Disease.
作者信息
Kazazian Haig H, Moran John V
机构信息
From the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore (H.H.K.), and the Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, Ann Arbor (J.V.M.).
出版信息
N Engl J Med. 2017 Jul 27;377(4):361-370. doi: 10.1056/NEJMra1510092.
Abstract
摘要
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Somatically Acquired LINE-1 Insertions in Normal Esophagus Undergo Clonal Expansion in Esophageal Squamous Cell Carcinoma.正常食管中体细胞获得的LINE-1插入在食管鳞状细胞癌中发生克隆性扩增。
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Discovery of an Active RAG Transposon Illuminates the Origins of V(D)J Recombination.活性RAG转座子的发现揭示了V(D)J重组的起源。
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A hot L1 retrotransposon evades somatic repression and initiates human colorectal cancer.一个活跃的L1反转录转座子逃避体细胞抑制并引发人类结直肠癌。
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