a Center for Cancer Treatment , Sorlandet Hospital Trust , Kristiansand , Norway.
b Department of Health and Sport Science , University of Agder , Kristiansand , Norway.
Acta Oncol. 2018 Jun;57(6):831-838. doi: 10.1080/0284186X.2017.1413247. Epub 2017 Dec 14.
This study aimed to explore the feasibility of an individualized comprehensive lifestyle intervention in cancer patients undergoing curative or palliative chemotherapy.
At one cancer center, serving a population of 180,000, 100 consecutive of 161 eligible newly diagnosed cancer patients starting curative or palliative chemotherapy entered a 12-month comprehensive, individualized lifestyle intervention. Participants received a grouped startup course and monthly counseling, based on self-reported and electronically evaluated lifestyle behaviors. Patients with completed baseline and end of study measurements are included in the final analyses. Patients who did not complete end of study measurements are defined as dropouts.
More completers (n = 61) vs. dropouts (n = 39) were married or living together (87 vs. 69%, p = .031), and significantly higher baseline physical activity levels (960 vs. 489 minwk, p = .010), more healthy dietary choices (14 vs 11 points, p = .038) and fewer smokers (8 vs. 23%, p = .036) were observed among completers vs. dropouts. Logistic regression revealed younger (odds ratios (OR): 0.95, 95% confidence interval (CI): 0.91, 0.99) and more patients diagnosed with breast cancer vs. more severe cancer types (OR: 0.16, 95% CI: 0.04, 0.56) among completers vs. dropouts. Improvements were observed in completers healthy (37%, p < 0.001) and unhealthy dietary habits (23%, p = .002), and distress (94%, p < .001). No significant reductions were observed in physical activity levels. Patients treated with palliative intent did not reduce their physical activity levels while healthy dietary habits (38%, p = 0.021) and distress (104%, p = 0.012) was improved.
Favorable and possibly clinical relevant lifestyle changes were observed in cancer patients undergoing curative or palliative chemotherapy after a 12-month comprehensive and individualized lifestyle intervention. Palliative patients were able to participate and to improve their lifestyle behaviors.
本研究旨在探索对接受根治性或姑息性化疗的癌症患者进行个体化综合生活方式干预的可行性。
在一家服务人口为 18 万的癌症中心，100 名连续的 161 名符合条件的新诊断癌症患者，开始接受根治性或姑息性化疗，参加了为期 12 个月的综合个体化生活方式干预。参与者根据自我报告和电子评估的生活方式行为接受分组启动课程和每月咨询。完成基线和研究结束测量的患者纳入最终分析。未完成研究结束测量的患者被定义为脱落者。
更多的完成者（n=61）与脱落者（n=39）相比，已婚或同居（87%比 69%，p=0.031），以及更高的基线体力活动水平（960 比 489minwk，p=0.010），更健康的饮食选择（14 比 11 分，p=0.038）和更少的吸烟者（8 比 23%，p=0.036），在完成者中观察到。与脱落者相比，完成者中年龄较小（比值比（OR）：0.95，95%置信区间（CI）：0.91，0.99）和更多的乳腺癌患者被诊断出（OR：0.16，95%CI：0.04，0.56）。在完成者中观察到健康（37%，p<0.001）和不健康的饮食习惯（23%，p=0.002）和痛苦（94%，p<0.001）的改善。在体力活动水平方面没有观察到显著降低。接受姑息治疗的患者在改善健康饮食习惯（38%，p=0.021）和减轻痛苦（104%，p=0.012）的同时，没有降低他们的体力活动水平。
在接受根治性或姑息性化疗的癌症患者中，进行为期 12 个月的综合个体化生活方式干预后，观察到有利的且可能具有临床相关性的生活方式改变。姑息治疗患者能够参与并改善他们的生活方式行为。
