母体肝移植：应用游离胎儿 DNA 检测导致胎儿性别不一致的另一个原因。
Maternal liver transplant: Another cause of discordant fetal sex determination using cell-free DNA.
机构信息
Laboratory for Cytogenetics and Genome Research, KU Leuven, Leuven, Belgium.
Centre for Human Genetics, KU Leuven, Leuven, Belgium.
出版信息
Prenat Diagn. 2018 Jan;38(2):148-150. doi: 10.1002/pd.5194. Epub 2018 Jan 4.
Noninvasive prenatal testing (NIPT) can very accurately determine fetal sex during pregnancy. We present an exceptional case where NIPT contradicts the ultrasound-based sex determination. The pregnant woman was recipient of a liver transplant from a male donor. Graft-derived cell-free DNA released into the maternal circulation clouded the NIPT-based sex determination. Hence, NIPT is not advisable when the pregnant mother underwent an organ transplant.
无创产前检测 (NIPT) 可以非常准确地确定怀孕期间胎儿的性别。我们呈现了一个特殊的案例，其中 NIPT 与基于超声的性别确定结果相矛盾。该孕妇是一名男性供体肝移植的受者。移植细胞游离 DNA 释放到母体循环中，使基于 NIPT 的性别确定结果变得模糊。因此，当孕妇接受器官移植时，不建议使用 NIPT。
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