a School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara , São Paulo , Brazil.
b School of Chemistry, São Paulo State University (UNESP), Araraquara , São Paulo , Brazil.
Crit Rev Anal Chem. 2018 Mar 4;48(2):110-118. doi: 10.1080/10408347.2017.1416283. Epub 2018 Feb 2.
Paclitaxel is a diterpenoid pseudoalkaloid, isolated from Taxus brevifolia, and is largely used as an antitumoral drug. The formulation of paclitaxel known as Taxol® employs a mixture of Cremophor EL and dehydrated ethanol, due the low drug water solubility. However, Taxol® causes some unwanted side effects due to the presence of Cremophor EL and ethanol in the formulation. Based on this, there is a need for the development of drug delivery systems to enhance the solubility, permeability and stability of paclitaxel and to promote a controlled and targeted delivery for better therapeutic effect and reduced side effects. In addition, the drug has been qualitatively and quantitatively analyzed in different delivery systems. In this context, several approaches were reported focusing on the optimization of analytical methods and development of new ones, considering the need of a fast, simple, with enough sensibility and selectivity assay, which can be a problem in some analysis. This review presents a summary of methods used in quantification of paclitaxel in different matrices, such as plasma, urine, plant extract, cells and delivery systems.
紫杉醇是一种从短叶红豆杉中分离得到的二萜类伪生物碱，主要用作抗肿瘤药物。商品名为 Taxol®的紫杉醇制剂采用聚氧乙烯蓖麻油 EL 和脱水乙醇的混合物，因为药物在水中的溶解度低。然而，由于配方中存在聚氧乙烯蓖麻油 EL 和乙醇，Taxol®会引起一些不良反应。基于这一点，需要开发药物传递系统来提高紫杉醇的溶解度、渗透性和稳定性，并促进其可控和靶向传递，以获得更好的治疗效果和降低副作用。此外，已经在不同的传递系统中对药物进行了定性和定量分析。在这种情况下，已经报道了几种方法，侧重于优化分析方法和开发新方法，考虑到需要一种快速、简单、具有足够灵敏度和选择性的分析方法，这在某些分析中可能是一个问题。本文综述了不同基质（如血浆、尿液、植物提取物、细胞和传递系统）中紫杉醇定量分析的方法。
