Patel Priya, Garala Kevinkumar, Singh Sudarshan, Prajapati Bhupendra G, Chittasupho Chuda
Department of Pharmaceutical Sciences, Saurashtra University, Rajkot 360005, Gujarat, India.
School of Pharmaceutical Sciences, Atmiya University, Rajkot 360005, Gujarat, India.
Pharmaceuticals (Basel). 2024 Mar 1;17(3):329. doi: 10.3390/ph17030329.
In recent years, due to their distinctive and adaptable therapeutic effects, many natural bioactive compounds have been commonly used to treat diseases. Their limited solubility, low bioavailability, inadequate gastrointestinal tract stability, high metabolic rate, and shorter duration of action limited their pharmaceutical applications. However, those can be improved using nanotechnology to create various drug delivery systems, including lipid-based nanoparticles, to adjust the compounds' physicochemical properties and pharmacokinetic profile. Because of the enormous technical advancements made in the fundamental sciences and the physical and chemical manipulation of individual atoms and molecules, the subject of nanotechnology has experienced revolutionary growth. By fabricating certain functionalized particles, nanotechnology opens an innovative horizon in research and development for overcoming restrictions, including traditional medication administration systems. Nanotechnology-driven bioactive compounds are certain to have a high impact and clinical value for current and future uses. Lipid-based nanotechnologies were shown to deliver a range of naturally occurring bioactive compounds with decent entrapment potential and stability, a successfully controlled release, increased bioavailability, and intriguing therapeutic activity. This review outlines bioactive compounds such as paclitaxel, curcumin, rhodomyrtone, quercetin, kaempferol, resveratrol, epigallocatechin-3-gallate, silymarin, and oridonin, fortified within either a natural or synthetic lipid-based drug delivery system based on nanotechnology and their evaluation and clinical considerations.
近年来，由于其独特且适应性强的治疗效果，许多天然生物活性化合物已被广泛用于治疗疾病。然而，它们有限的溶解度、低生物利用度、胃肠道稳定性不足、高代谢率和较短的作用持续时间限制了其药物应用。不过，利用纳米技术创建各种药物递送系统，包括基于脂质的纳米颗粒，可以改善这些问题，以调整化合物的物理化学性质和药代动力学特征。由于基础科学以及对单个原子和分子的物理和化学操纵取得了巨大的技术进步，纳米技术这一学科经历了革命性的发展。通过制造某些功能化颗粒，纳米技术为克服包括传统药物给药系统在内的限制开辟了创新的研发视野。纳米技术驱动的生物活性化合物对于当前和未来的应用肯定具有重大影响和临床价值。基于脂质的纳米技术已显示出能够递送一系列天然存在的生物活性化合物，具有良好的包封潜力和稳定性、成功的控释、提高的生物利用度以及有趣的治疗活性。本综述概述了诸如紫杉醇、姜黄素、玫红酮、槲皮素、山奈酚、白藜芦醇、表没食子儿茶素 - 3 - 没食子酸酯、水飞蓟宾和冬凌草甲素等生物活性化合物，这些化合物被强化在基于纳米技术的天然或合成脂质药物递送系统中，以及它们的评估和临床考量。
