Institute of Diabetes and Obesity, Helmholtz Zentrum München, Munich, Germany.
Institute of Diabetes and Obesity, Helmholtz Zentrum München, Munich, Germany; Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Penzberg, 82377 Penzberg, Germany.
Trends Biochem Sci. 2018 Jan;43(1):1-4. doi: 10.1016/j.tibs.2017.11.003. Epub 2017 Nov 24.
Diverse gene regulatory mechanisms impact on immune homeostasis, and a new model now emerges as fundamental in light of recent genome-wide studies. In this picture, transcriptional networks drive functional changes during immune activation, whereas autoregulatory feedback loops of post-transcriptional programs ensure the original cell lineage identity and subsequent immune resolution.
多种基因调控机制影响免疫稳态，而最近的全基因组研究表明，一个新模型现在变得至关重要。在这个模型中，转录网络在免疫激活过程中驱动功能变化，而转录后程序的自动反馈回路则确保原始细胞谱系的身份和随后的免疫缓解。
