巨噬细胞中的克雷布斯循环中断。
A broken krebs cycle in macrophages.
机构信息
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland.
出版信息
Immunity. 2015 Mar 17;42(3):393-4. doi: 10.1016/j.immuni.2015.02.017.
PMID:25786167
Abstract
Macrophages undergo metabolic rewiring during polarization but details of this process are unclear. In this issue of Immunity, Jha et al. (2015) report a systems approach for unbiased analysis of cellular metabolism that reveals key metabolites and metabolic pathways required for distinct macrophage polarization states.
摘要
巨噬细胞在极化过程中经历代谢重编程，但这一过程的细节尚不清楚。在本期《免疫》杂志上，Jha 等人（2015）报道了一种用于细胞代谢无偏分析的系统方法，该方法揭示了不同巨噬细胞极化状态所需的关键代谢物和代谢途径。
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