建立对营养波动的动力学响应模型。

Modelling the Kinetic Response to Nutrient Fluctuations.

机构信息

Department of Biology, University of Florence, Italy.

出版信息

Trends Microbiol. 2018 Jan;26(1):4-5. doi: 10.1016/j.tim.2017.11.009. Epub 2017 Nov 24.

DOI:10.1016/j.tim.2017.11.009

Abstract

Understanding and predicting how microbes respond to environmental fluctuations is a central challenge in present-day microbiology. Erickson et al. have proposed a quantitative and (kinetic) parameters-free model of Escherichia coli growth that successfully anticipates changes in gene expression and biomass accumulation in response to nutrients up- and down-shifts.

摘要

理解和预测微生物如何应对环境波动是当今微生物学的一个核心挑战。Erickson 等人提出了一种定量的且（不含）动力学参数的大肠杆菌生长模型，该模型成功地预测了响应营养物质的升/降变化时基因表达和生物量积累的变化。