Aimetti Mario, Ferrarotti Francesco, Gamba Mara Noemi, Giraudi Marta, Romano Federica
Int J Periodontics Restorative Dent. 2018 Jan/Feb;38(1):51-58. doi: 10.11607/prd.3425.
The present case series aimed to explore the potential clinical benefits of the application of dental pulp stem cells (DPSCs) in the regenerative treatment of deep intrabony defects. A total of 11 isolated intrabony defects in 11 chronic periodontitis patients were accessed with a minimally invasive flap and filled with DPSCs loaded on a collagen sponge. A tooth requiring extraction for impaction or malpositioning was used as an autologous source for DPSCs. An average clinical attachment level gain of 4.7 ± 1.5 mm associated with a residual mean probing depth (PD) of 3.2 ± 0.9 mm and remarkable stability of the gingival margin was observed at 1 year. Complete pocket closure (PD < 3 mm) was achieved in 63.6% of the experimental sites. Clinical outcomes were supported by the radiographic analysis showing a bone fill of 3.6 ± 1.9 mm.
本病例系列旨在探讨牙髓干细胞（DPSCs）在深部骨内缺损再生治疗中应用的潜在临床益处。对11例慢性牙周炎患者的11个孤立骨内缺损采用微创瓣入路，并填充负载于胶原海绵上的DPSCs。将因阻生或错位而需拔除的牙齿作为DPSCs的自体来源。1年后观察到平均临床附着水平增加4.7±1.5 mm，残余平均探诊深度（PD）为3.2±0.9 mm，牙龈边缘具有显著稳定性。63.6%的试验位点实现了袋完全闭合（PD<3 mm）。影像学分析显示骨填充为3.6±1.9 mm，支持了临床结果。
