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源自牙组织的间充质干细胞相关长链非编码RNA：成骨分化中的新型调节因子

Mesenchymal Stem Cell-Derived from Dental Tissues-Related lncRNAs: A New Regulator in Osteogenic Differentiation.

作者信息

Zhang Yinchun, Chen Xuan, Yang XiaoXia, Huang Lei, Qiu Xiaoling

机构信息

Department of Endodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangdong 510280, China.

出版信息

J Tissue Eng Regen Med. 2023 Jul 4;2023:4622584. doi: 10.1155/2023/4622584. eCollection 2023.

DOI:10.1155/2023/4622584
PMID:40226409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11919082/
Abstract

Odontogenic stem cells are mesenchymal stem cells (MSCs) with multipotential differentiation potential from different dental tissues. Their osteogenic differentiation is of great significance in bone tissue engineering. In recent years, it has been found that long noncoding RNAs (lncRNAs) participate in regulating the osteoblastic differentiation of stem cells at the epigenetic level, transcriptional level, and posttranscriptional level. We reviewed the existing lncRNA related to the osteogenic differentiation of odontogenic stem cells and emphasized the critical mechanism of lncRNA in the osteogenic differentiation of odontogenic stem cells. These findings are expected to be an important target for promoting osteoblastic differentiation of odontogenic stem cells in bone regeneration therapy with lncRNA.

摘要

牙源性干细胞是来自不同牙组织的具有多向分化潜能的间充质干细胞。它们的成骨分化在骨组织工程中具有重要意义。近年来，人们发现长链非编码RNA（lncRNA）在表观遗传水平、转录水平和转录后水平参与调控干细胞的成骨分化。我们综述了与牙源性干细胞成骨分化相关的现有lncRNA，并强调了lncRNA在牙源性干细胞成骨分化中的关键机制。这些发现有望成为在基于lncRNA的骨再生治疗中促进牙源性干细胞成骨分化的重要靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/600a/11919082/f5f94240dc9f/JTERM2023-4622584.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/600a/11919082/e5be9f4174d0/JTERM2023-4622584.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/600a/11919082/be9dcf56ee77/JTERM2023-4622584.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/600a/11919082/1ba8a43b6648/JTERM2023-4622584.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/600a/11919082/a079f6e42db3/JTERM2023-4622584.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/600a/11919082/f5f94240dc9f/JTERM2023-4622584.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/600a/11919082/e5be9f4174d0/JTERM2023-4622584.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/600a/11919082/be9dcf56ee77/JTERM2023-4622584.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/600a/11919082/1ba8a43b6648/JTERM2023-4622584.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/600a/11919082/a079f6e42db3/JTERM2023-4622584.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/600a/11919082/f5f94240dc9f/JTERM2023-4622584.005.jpg

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本文引用的文献

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The lncRNA epigenetics: The significance of m6A and m5C lncRNA modifications in cancer.长链非编码RNA表观遗传学：m6A和m5C长链非编码RNA修饰在癌症中的意义
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Long non-coding RNA IGFBP7-AS1 accelerates the odontogenic differentiation of stem cells from human exfoliated deciduous teeth by regulating IGFBP7 expression.
长非编码 RNA IGFBP7-AS1 通过调节 IGFBP7 的表达加速人脱落乳牙干细胞的成牙分化。
Hum Cell. 2022 Nov;35(6):1697-1707. doi: 10.1007/s13577-022-00763-9. Epub 2022 Aug 29.
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miR-490-3p Alleviates Cardiomyocyte Injury via Targeting FOXO1.微小RNA-490-3p通过靶向叉头框蛋白O1减轻心肌细胞损伤。
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A reduced level of the long non-coding RNA SNHG8 activates the NF-kappaB pathway by releasing functional HIF-1alpha in a hypoxic inflammatory microenvironment.长链非编码 RNA SNHG8 水平降低可在缺氧炎症微环境中通过释放功能性 HIF-1α 激活 NF-κB 通路。
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