百日咳毒素对可乐定和育亨宾微量注入蓝斑后所诱导的行为及脑电图频谱变化的影响。
Effects of pertussis toxin on the behavioural and ECoG spectrum changes induced by clonidine and yohimbine after their microinfusion into the locus coeruleus.
作者信息
De Sarro G B, Bagetta G, Ascioti C, Libri V, Nisticò G
机构信息
Institute of Pharmacology, Faculty of Medicine, Catanzaro, University of Reggio Calabria, Italy.
出版信息
Br J Pharmacol. 1989 Jan;96(1):59-64. doi: 10.1111/j.1476-5381.1989.tb11784.x.
Abstract
- Pertussis toxin, a substance which interferes selectively with receptor-mediated signal transduction mechanisms, was injected into the locus coeruleus of rats 1, 2, 3, 6 or 10 days before the microinjection of clonidine or yohimbine into the same site. 2. Clonidine produced in control rats typical behavioural sedation and/or sleep and ECoG synchronization while yohimbine produced behavioural arousal and ECoG desynchronization. 3. The behavioural and ECoG effects of both compounds were blocked in animals pretreated with pertussis toxin. This activity was more marked from 2 to 6 days after pertussis toxin pretreatment and was restored 10 days after toxin administration. In addition, the behavioural and ECoG slow-wave sleep observed after intraperitoneal administration of clonidine (0.2 mumol kg-1) was significantly reduced by prior (3 days) microinfusion of pertussis toxin into the locus coeruleus. 4. These results are consistent with the hypothesis that the behavioural and ECoG effects of clonidine and yohimbine are mediated via a guanine regulatory protein which is affected by pertussis toxin.
摘要
- 百日咳毒素是一种能选择性干扰受体介导信号转导机制的物质，在向大鼠蓝斑微量注射可乐定或育亨宾前1、2、3、6或10天，将其注入大鼠蓝斑。2. 可乐定在对照大鼠中产生典型的行为镇静和/或睡眠以及脑电图同步，而育亨宾则产生行为觉醒和脑电图去同步。3. 两种化合物的行为和脑电图效应在用百日咳毒素预处理的动物中被阻断。这种作用在百日咳毒素预处理后2至6天更为明显，并在毒素给药后10天恢复。此外，在向蓝斑微量注射百日咳毒素（3天前）后，腹腔注射可乐定（0.2 μmol kg-1）后观察到的行为和脑电图慢波睡眠显著减少。4. 这些结果与以下假设一致，即可乐定和育亨宾的行为和脑电图效应是通过受百日咳毒素影响的鸟嘌呤调节蛋白介导的。
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Mechanism of pertussis toxin action on the adenylate cyclase system. Inhibition of the turn-on reaction of the inhibitory regulatory site.百日咳毒素对腺苷酸环化酶系统的作用机制。抑制抑制性调节位点的开启反应。
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