Wáng Yì Xiáng J, Deng Min, Lin Jiang, Kwok Anthony W L, Liu Eric K W, Chen Weitian
1 Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong SAR.
2 Department of Radiology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
SLAS Technol. 2018 Apr;23(2):179-187. doi: 10.1177/2472630317747198. Epub 2017 Dec 14.
To understand women's and men's physiological ranges of liver T1rho relaxation time measured with a single breathhold black blood sequence, this healthy volunteer study was conducted in 62 women (mean age, 38.9 y; range, 18-75 y) and 34 men (mean age, 44.7 y; range, 24-80 y). Approval from the institutional ethics committee was obtained. Magnetic resonance imaging was performed with a 3.0T scanner with six spin-lock times of 0, 10, 20, 25, 35, and 50 ms and a single breathhold of 12 s per slice acquisition. Six slices were acquired for each examination. The results demonstrated that the female liver T1rho value ranged between 35.07 and 51.97 ms and showed an age-dependent decrease, with younger women having a higher measurement. The male liver T1rho value ranged between 34.94 and 43.39 ms, with no evidential age dependence. Postmenopausal women had similar liver T1rho values as men. For women, there was a trend that the liver T1rho value could be 4% to 5% lower during the menstrual phase than during the nonmenstrual phase. For both women and men, no evidential association was seen between body mass index and liver T1rho.
为了解使用单次屏气黑血序列测量的女性和男性肝脏T1rho弛豫时间的生理范围，本健康志愿者研究纳入了62名女性（平均年龄38.9岁；范围18 - 75岁）和34名男性（平均年龄44.7岁；范围24 - 80岁）。获得了机构伦理委员会的批准。使用3.0T扫描仪进行磁共振成像，自旋锁定时间分别为0、10、20、25、35和50毫秒，每采集一层图像进行一次12秒的屏气。每次检查采集6层图像。结果表明，女性肝脏T1rho值在35.07至51.97毫秒之间，且呈年龄依赖性下降，年轻女性的测量值更高。男性肝脏T1rho值在34.94至43.39毫秒之间，无明显年龄依赖性。绝经后女性的肝脏T1rho值与男性相似。对于女性，有一个趋势是，月经周期中的肝脏T1rho值可能比非月经周期低4%至5%。对于女性和男性，体重指数与肝脏T1rho之间均无明显关联。
