社区性健康诊所中男男性行为者的HIV暴露前预防（PrEP）的接受和持续情况
HIV Pre-exposure Prophylaxis (PrEP) Uptake and Retention Among Men Who Have Sex with Men in a Community-Based Sexual Health Clinic.
作者信息
Hojilla J Carlo, Vlahov David, Crouch Pierre-Cedric, Dawson-Rose Carol, Freeborn Kellie, Carrico Adam
机构信息
Department of Community Health Systems, School of Nursing, University of California, San Francisco, CA, USA.
School of Nursing, Yale University, West Haven, CT, USA.
出版信息
AIDS Behav. 2018 Apr;22(4):1096-1099. doi: 10.1007/s10461-017-2009-x.
Abstract
In a community-based clinic serving men who have sex with men in San Francisco, California, this study characterized key steps of the pre-exposure prophylaxis (PrEP) cascade and identified correlates of retention in care. In total, 344 patients were evaluated for PrEP. Three-fourths (78%) of those who sought PrEP services initiated PrEP. The overall cumulative incidence of discontinuing PrEP at 13 months was 38%. Men with a sexually transmitted infection (STI) were 44% less likely to be retained (adjusted hazard ratio [aHR] 0.56, 95% confidence interval [0.33-0.95]). Comprehensive retention efforts for men with STIs are crucial to optimize the benefits of PrEP.
摘要
在加利福尼亚州旧金山一家为男同性恋者服务的社区诊所，本研究描述了暴露前预防（PrEP）流程的关键步骤，并确定了坚持治疗的相关因素。共有344名患者接受了PrEP评估。寻求PrEP服务的患者中有四分之三（78%）开始使用PrEP。13个月时停止使用PrEP的总体累积发生率为38%。患有性传播感染（STI）的男性坚持治疗的可能性要低44%（调整后风险比[aHR]为0.56，95%置信区间[0.33 - 0.95]）。对患有性传播感染的男性采取全面的坚持治疗措施对于优化PrEP的益处至关重要。
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