Wickner Reed B, Edskes Herman K, Bezsonov Evgeny E, Son Moonil, Ducatez Mathieu
Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892-0830, USA.
Curr Genet. 2018 Jun;64(3):571-574. doi: 10.1007/s00294-017-0788-2. Epub 2017 Dec 14.
The [PSI+] prion is a folded in-register parallel β-sheet amyloid (filamentous polymer) of Sup35p, a subunit of the translation termination factor. Our searches for anti-prion systems led to our finding that certain soluble inositol polyphosphates (IPs) are important for the propagation of the [PSI+] prion. The IPs affect a wide range of processes, including mRNA export, telomere length, phosphate and polyphosphate metabolism, energy regulation, transcription and translation. We found that 5-diphosphoinositol tetra(or penta)kisphosphate or inositol hexakisphosphate could support [PSI+] prion propagation, and 1-diphosphoinositol pentakisphosphate appears to inhibit the process.
[PSI+] 朊病毒是翻译终止因子的一个亚基Sup35p折叠成的同向平行β-片层淀粉样蛋白（丝状聚合物）。我们对抗朊病毒系统的研究发现，某些可溶性肌醇多磷酸（IPs）对[PSI+] 朊病毒的传播很重要。IPs影响广泛的过程，包括mRNA输出、端粒长度、磷酸盐和多聚磷酸盐代谢、能量调节、转录和翻译。我们发现5-二磷酸肌醇四（或五）磷酸或肌醇六磷酸可以支持[PSI+] 朊病毒的传播，而1-二磷酸肌醇五磷酸似乎会抑制这一过程。
