Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda 20892-0830, MD, USA.
Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda 20892-0830, MD, USA.
J Mol Biol. 2018 Oct 12;430(20):3707-3719. doi: 10.1016/j.jmb.2018.04.022. Epub 2018 Apr 24.
Saccharomyces cerevisiae is an occasional host to an array of prions, most based on self-propagating, self-templating amyloid filaments of a normally soluble protein. [URE3] is a prion of Ure2p, a regulator of nitrogen catabolism, while [PSI+] is a prion of Sup35p, a subunit of the translation termination factor Sup35p. In contrast to the functional prions, [Het-s] of Podospora anserina and [BETA] of yeast, the amyloid-based yeast prions are rare in wild strains, arise sporadically, have an array of prion variants for a single prion protein sequence, have a folded in-register parallel β-sheet amyloid architecture, are detrimental to their hosts, arouse a stress response in the host, and are subject to curing by various host anti-prion systems. These characteristics allow a logical basis for distinction between functional amyloids/prions and prion diseases. These infectious yeast amyloidoses are outstanding models for the many common human amyloid-based diseases that are increasingly found to have some infectious characteristics.
酿酒酵母是多种朊病毒的偶然宿主，大多数基于自我传播、自我模板化的正常可溶性蛋白的淀粉样纤维。[URE3]是 Ure2p 的朊病毒，是氮代谢调节剂，而[PSI+]是 Sup35p 的朊病毒，Sup35p 是翻译终止因子 Sup35p 的亚基。与功能性朊病毒相反，[Het-s]的 Podospora anserina 和 [BETA]的酵母，基于淀粉样的酵母朊病毒在野生菌株中很少见，偶尔出现，具有一系列同种朊病毒蛋白序列的朊病毒变体，具有折叠的平行β-片层淀粉样结构，对其宿主有害，引起宿主应激反应，并受到各种宿主抗朊病毒系统的治疗。这些特征为功能性淀粉样蛋白/朊病毒和朊病毒疾病之间的区别提供了合理的基础。这些传染性酵母淀粉样变是许多常见的人类基于淀粉样蛋白的疾病的杰出模型，这些疾病越来越多地被发现具有一些传染性特征。
