Department of Obstetrics and Gynaecology, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa.
Department of Human Nutrition, Tygerberg Hospital, Cape Town, South Africa.
Int J Gynaecol Obstet. 2018 Apr;141(1):85-90. doi: 10.1002/ijgo.12427. Epub 2018 Jan 21.
To compare a glucose test based on a standardized, designed breakfast to the 75-g oral glucose tolerance test (OGTT), comparing venous and capillary glucose values for the diagnosis of gestational diabetes mellitus (GDM).
The present prospective, randomized, cross-over trial enrolled patients at high risk of developing GDM who were attending the High-Risk Antenatal Clinic of Tygerberg Hospital, Cape Town, South Africa, between March 1 and December 31, 2015. Patients were randomized to initial testing with either the OGTT or a designed breakfast glucose profile (DBGP) glucose test before the alternate test was performed 1 week later; no dietary or other interventions were applied in the intervening period. Venous and capillary fasting and 2-hour glucose values were measured and were compared between the OGTT and DBGP, and between OGTT and laboratory venous samples.
There were 51 patients included in the study. The fasting and 2-hour capillary glucose values from the OGTT correlated significantly with the laboratory venous samples (P<0.001 at both time intervals). The 2-hour capillary glucose values from the DBGP demonstrated a satisfactory correlation with those from the OGTT (P<0.001).
The DBGP provided a sufficiently accurate alternate test for the diagnosis of GDM; it warrants further investigation.
比较基于标准化设计早餐的血糖测试与 75g 口服葡萄糖耐量试验（OGTT），比较静脉和毛细血管血糖值用于诊断妊娠期糖尿病（GDM）。
本前瞻性、随机、交叉试验纳入了 2015 年 3 月 1 日至 12 月 31 日在南非开普敦泰格伯格医院高危产前诊所就诊的高危 GDM 患者。患者在初始测试时随机接受 OGTT 或设计的早餐血糖谱（DBGP）血糖测试，一周后进行另一种测试；在间隔期间不进行饮食或其他干预。测量静脉和毛细血管空腹和 2 小时血糖值，并在 OGTT 和 DBGP 之间以及 OGTT 和实验室静脉样本之间进行比较。
本研究共纳入 51 例患者。OGTT 的空腹和 2 小时毛细血管血糖值与实验室静脉样本显著相关（两个时间点的 P<0.001）。DBGP 的 2 小时毛细血管血糖值与 OGTT 的结果具有良好的相关性（P<0.001）。
DBGP 为 GDM 的诊断提供了一种足够准确的替代试验；它值得进一步研究。
