Komuro T
Department of Anatomy, School of Medicine Ehime University, Japan.
Cell Tissue Res. 1989 Feb;255(2):343-51. doi: 10.1007/BF00224117.
An extensive cellular network becomes visible over the myenteric plexus of the rat after removal of the overlying tissues under the scanning electron microscope. The cells are mainly stellate and have many slender processes via which they interconnect. They form a three-dimensional network and are closely associated with the ganglia and nerve bundles, and also extend over the smooth muscle cells. They are considered to correspond to the interstitial cells of Cajal because of their peculiar arrangement and their topography. Transmission electron-microscopic evidence demonstrates that the majority of those cells have features of fibroblasts. Gap junctions and intermediate junctions are observed between these fibroblast-like cells, and also between them and smooth muscle cells. Examination of serial thin sections reveals that single fibroblast-like interstitial cells connect to both circular and longitudinal muscle cells via gap junctions. It is suggested that the network of interstitial cells conducts electrical signals.
在扫描电子显微镜下移除大鼠肌间神经丛上方的组织后，可看到一个广泛的细胞网络。这些细胞主要呈星状，有许多细长的突起，通过这些突起它们相互连接。它们形成一个三维网络，与神经节和神经束紧密相连，并且还延伸到平滑肌细胞上。由于其特殊的排列方式和位置，它们被认为与Cajal间质细胞相对应。透射电子显微镜证据表明，这些细胞中的大多数具有成纤维细胞的特征。在这些成纤维细胞样细胞之间，以及它们与平滑肌细胞之间，均观察到缝隙连接和中间连接。对连续薄切片的检查显示，单个成纤维细胞样间质细胞通过缝隙连接与环形肌细胞和纵行肌细胞相连。有人提出，间质细胞网络传导电信号。
