Girard L J, Veselinovic A, Font R L
Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas.
Cornea. 1989;8(1):7-14.
A 45-year-old man who had uneventful excision of bilateral pingueculae developed bilateral membranous lesions involving the bulbar conjunctivae and corneas. Histologically, the membranes were composed mainly of large fibrinous deposits intermixed with acute and chronic inflammatory cells with areas of fibroblastic and capillary proliferation resembling granulation tissue. By electronmicroscopy the amorphous acidophilic masses were composed of electron-dense, fibrillar material with a periodicity of 10-12 mm, which was consistent with fibrin. Despite mechanical removal of the membranes, they continued to recur rapidly over a period of several months. The lesions apparently responded slowly to topical enzymatic therapy that consisted of hyaluronidase (175 U/ml) and alpha-chymotrypsin (1:5000) drops. Follow-up examination, approximately 1 year after surgery, revealed that the patient was asymptomatic. Ocular examination disclosed slight persistence of gelatinous membranes on the bulbar conjunctivae, most prominent in the left eye.
一名45岁男性，双侧睑裂斑切除术后恢复顺利，却出现了累及球结膜和角膜的双侧膜性病变。组织学检查显示，这些膜主要由大量纤维蛋白沉积物组成，混有急性和慢性炎症细胞，并有类似肉芽组织的成纤维细胞和毛细血管增生区域。电子显微镜检查发现，无定形嗜酸性团块由电子致密的纤维状物质组成，其周期为10 - 12毫米，与纤维蛋白一致。尽管通过机械方法去除了这些膜，但在几个月的时间里它们仍迅速复发。病变对由透明质酸酶（175 U/ml）和α - 糜蛋白酶（1:5000）滴眼液组成的局部酶疗反应明显较慢。术后约1年的随访检查显示，患者无症状。眼部检查发现球结膜上仍有轻微的凝胶状膜残留，左眼最为明显。
