Centre for Ethics Law and Mental Health (CELAM) Institute of Neuroscience and Physiology, University of Gothenburg, SU Rättspsykiatri, Rågårdsvägen 5, Enhet CELAM Hus 1, SE-424 57 Gunnilse, Gothenburg, Sweden.
Department of Forensic Psychiatry, Sahlgrenska University Hospital, SU Rättspsykiatri, Rågårdsvägen 5, SE-424 57 Gunnilse, Gothenburg, Sweden.
BMC Psychiatry. 2017 Dec 16;17(1):403. doi: 10.1186/s12888-017-1563-0.
Reliable and easy to administer screening instruments focusing on neurodevelopmental disorders and associated conditions are scarce. The Autism-Tics, AD/HD and other Comorbidities inventory (A-TAC) has previously been validated and reporting good- excellent validity for several disorders. This article aims to expand these findings by including more conditions in a substantially larger sample augmented with the Swedish National Patient Register (NPR).
Since 2004 parents of all 9-year-old Swedish twins have been invited to participate in a telephone interview in the Child and Adolescent Twin Study in Sweden, CATSS. The CATSS is linked to the NPR which includes data from in- and outpatient care. Data on neurodevelopmental disorders (A-TAC) collected in CATSS were compared with diagnoses from the NPR. We investigated diagnoses that had been made both before (previous validity) and after (predictive validity) the interview.
Sensitivity and specificity of A-TAC scores for predicting earlier or later clinical diagnoses were mostly good-excellent, with values of the area under the curve for a clinical diagnosis of autism spectrum disorder (ASD) of .98, attention deficit hyperactivity disorder (ADHD) .93, learning disorder (LD) .92, and oppositional defiant disorder (ODD) .99, with small differences in terms of previous and predictive analyses. A-TAC provided little validity for eating disorders.
The result support previous claims: A-TAC is a broad screening instrument with a particular strength in assessing ASD, ADHD, LD, and ODD at ages 9 and 12, and also provides phenotypic information about other child psychiatric disorders.
可靠且易于管理的、针对神经发育障碍及相关疾病的筛查工具十分匮乏。自闭症-抽动症、注意力缺陷多动障碍及其他共病问卷（A-TAC）此前已得到验证，对多种疾病具有良好-优秀的有效性。本文旨在通过纳入更多疾病，对该问卷进行扩展，对该问卷进行扩展，同时样本量大幅增加，并结合瑞典全国患者登记处（NPR）数据进行验证。
自 2004 年起，瑞典所有 9 岁的双胞胎儿童家长均被邀请参加瑞典儿童和青少年双胞胎研究（CATSS）的电话访谈。CATSS 与 NPR 相链接，后者包含门诊和住院护理的数据。在 CATSS 中收集的神经发育障碍（A-TAC）数据与 NPR 中的诊断数据进行比较。我们调查了在访谈之前（先前有效性）和之后（预测有效性）做出的诊断。
A-TAC 分数预测早期或晚期临床诊断的敏感性和特异性大多为良好-优秀，自闭症谱系障碍（ASD）、注意缺陷多动障碍（ADHD）、学习障碍（LD）和对立违抗性障碍（ODD）的曲线下面积（AUC）值分别为.98、.93、.92 和.99，预测分析与先前分析之间的差异较小。A-TAC 对进食障碍的有效性较低。
结果支持之前的研究结论：A-TAC 是一种广泛的筛查工具，在评估 9 岁和 12 岁儿童的 ASD、ADHD、LD 和 ODD 方面具有特别的优势，同时也为其他儿童精神障碍提供了表型信息。
