Droz Nina, Enouf Vincent, Bidet Philippe, Mohamed Damir, Behillil Sylvie, Simon Anne-Laure, Bachy Manon, Caseris Marion, Bonacorsi Stéphane, Basmaci Romain
Pediatric-Emergency Department, Louis-Mourier Hospital, AP-HP, Colombes, France.
Coordinating Center of the National Reference Center for Influenza Viruses, Institut Pasteur, UMR 3569 CNRS, Paris Diderot-Paris 7 University, Sorbonne Paris Cité.
J Pediatr. 2018 Jan;192:234-239.e2. doi: 10.1016/j.jpeds.2017.09.052.
To determine whether the seasonal distribution of Kingella kingae osteoarticular infections is similar to that of common respiratory viruses.
Between October 2009 and September 2016, we extracted the results of K kingae-specific real-time polymerase chain reaction analyses performed for bone or joint specimens in patients from 2 pediatric tertiary care centers in Paris. We used data of respiratory virus detection from the Réseau National des Laboratoires network with coordination with the National Influenza Center of France. The Spearman rank correlation was used to assess a correlation between weekly distributions, with P < .05 denoting a significant correlation.
During the 7-year study period, 322 children were diagnosed with K kingae osteoarticular infection, and 317 testing episodes were K kingae-negative. We observed high activity for both K kingae osteoarticular infection and human rhinovirus (HRV) during the fall (98 [30.4%] and 2401 [39.1%] cases, respectively) and low activity during summer (59 [18.3%] and 681 [11.1%] cases, respectively). Weekly distributions of K kingae osteoarticular infection and rhinovirus activity were significantly correlated (r = 0.30; P = .03). In contrast, no significant correlation was found between the weekly distribution of K kingae osteoarticular infection and other respiratory viruses (r = -0.17, P = .34 compared with respiratory syncytial virus; r = -0.13, P = .34 compared with influenza virus; and r = -0.22, P = .11 compared with metapneumovirus).
A significant temporal association was observed between HRV circulation and K kingae osteoarticular infection, strengthening the hypothesis of a role of viral infections in the pathophysiology of K kingae invasive infection.
确定金氏金杆菌骨关节炎感染的季节分布是否与常见呼吸道病毒相似。
2009年10月至2016年9月期间，我们提取了巴黎两家儿科三级护理中心对患者骨或关节标本进行的金氏金杆菌特异性实时聚合酶链反应分析结果。我们使用了法国国家流感中心协调的国家实验室网络的呼吸道病毒检测数据。采用Spearman等级相关分析每周分布之间的相关性，P < 0.05表示显著相关。
在7年的研究期间，322名儿童被诊断为金氏金杆菌骨关节炎感染，317次检测结果为金氏金杆菌阴性。我们观察到秋季金氏金杆菌骨关节炎感染和人鼻病毒（HRV）均处于高活动期（分别为98例[30.4%]和2401例[39.1%]），夏季活动水平较低（分别为59例[18.3%]和681例[11.1%]）。金氏金杆菌骨关节炎感染的每周分布与鼻病毒活动显著相关（r = 0.30；P = 0.03）。相比之下，金氏金杆菌骨关节炎感染的每周分布与其他呼吸道病毒之间未发现显著相关性（与呼吸道合胞病毒相比，r = -0.17，P = 0.34；与流感病毒相比，r = -0.13，P = 0.34；与偏肺病毒相比，r = -0.22，P = 0.11）。
观察到HRV传播与金氏金杆菌骨关节炎感染之间存在显著的时间关联，强化了病毒感染在金氏金杆菌侵袭性感染病理生理学中起作用的假说。
