Basmaci Romain, Bidet Philippe, Bonacorsi Stéphane
Service de Pédiatrie-Urgences, Hôpital Louis-Mourier, APHP, F-92700 Colombes, France.
Université de Paris, Inserm, IAME, UMR1137, F-75006 Paris, France.
Microorganisms. 2022 Jan 21;10(2):230. doi: 10.3390/microorganisms10020230.
() is an oropharyngeal commensal agent of toddlers and the primary cause of osteoarticular infections in 6-23-month-old children. Knowing that the oropharynx of young children is the reservoir and the portal of entry of , these results suggested that a viral infection may promote infection. In this narrative review, we report the current knowledge of the concomitance between and viral infections. This hypothesis was first suggested because some authors described that symptoms of viral infections were frequently concomitant with infection. Second, specific viral syndromes, such as hand, foot and mouth disease or stomatitis, have been described in children experiencing a infection. Moreover, some clusters of infection occurring in daycare centers were preceded by viral outbreaks. Third, the major viruses identified in patients during infection were human rhinovirus or coxsackievirus, which both belong to the Picornaviridae family and are known to facilitate bacterial infections. Finally, a temporal association was observed between human rhinovirus circulation and infection. Although highly probable, the role of viral infection in the pathophysiology remains unclear and is based on case description or temporal association. Molecular studies are needed.
（某病原体）是幼儿口咽部共生菌，也是6至23个月大儿童骨关节感染的主要病因。鉴于幼儿口咽部是该病原体的储存库和侵入门户，这些结果表明病毒感染可能会促进该病原体感染。在这篇叙述性综述中，我们报告了有关该病原体与病毒感染并存的现有知识。这一假设最初是因为一些作者描述病毒感染症状常与该病原体感染同时出现而提出的。其次，在感染该病原体的儿童中曾描述过特定的病毒综合征，如手足口病或口腔炎。此外，日托中心发生的一些该病原体感染聚集事件之前有病毒爆发。第三，在该病原体感染患者中鉴定出的主要病毒是人鼻病毒或柯萨奇病毒，它们都属于小RNA病毒科，并且已知会促进细菌感染。最后，观察到人类鼻病毒传播与该病原体感染之间存在时间关联。尽管病毒感染在该病原体病理生理学中的作用很可能存在，但仍不清楚，且基于病例描述或时间关联。需要进行分子研究。
