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溃疡性结肠炎:电镜研究,特别涉及隐窝脓肿的形成

Ulcerative colitis: electron microscopic studies with special reference to development of crypt abscesses.

作者信息

Balázs M, Kovács A

机构信息

Department of Pathology, János Hospital, Budapest, Hungary.

出版信息

Dis Colon Rectum. 1989 Apr;32(4):327-34. doi: 10.1007/BF02553489.

DOI:10.1007/BF02553489
PMID:2924672
Abstract

Electron microscopy of the colonic mucosa was performed in 33 patients with acute ulcerative colitis. The process of the development of crypt abscesses was studied. Inflammatory cells migrated intercellularly from the lamina propria and did not destruct the neighboring epithelial cells. Abnormal maturation of the epithelial cells was observed. Loose connection and separation of immature epithelial cells may promote migration of inflammatory cells.

摘要

对33例急性溃疡性结肠炎患者的结肠黏膜进行了电子显微镜检查。研究了隐窝脓肿的发展过程。炎症细胞从固有层进行细胞间迁移,未破坏相邻的上皮细胞。观察到上皮细胞的异常成熟。未成熟上皮细胞的连接松散和分离可能促进炎症细胞的迁移。

相似文献

1
Ulcerative colitis: electron microscopic studies with special reference to development of crypt abscesses.溃疡性结肠炎:电镜研究,特别涉及隐窝脓肿的形成
Dis Colon Rectum. 1989 Apr;32(4):327-34. doi: 10.1007/BF02553489.
2
Patterns of inflammation in mucosal biopsies of ulcerative colitis: perceived differences in pediatric populations are limited to children younger than 10 years.溃疡性结肠炎黏膜活检中的炎症模式:小儿群体中可察觉到的差异仅限于10岁以下儿童。
Am J Surg Pathol. 2004 Feb;28(2):183-9. doi: 10.1097/00000478-200402000-00005.
3
[Investigations on the ultrastructural pathology of the ulcerative colitis (author's transl)].
Virchows Arch A Pathol Anat Histol. 1975 Jul 17;367(2):113-30. doi: 10.1007/BF00430949.
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Colonic epithelial cells and polymorphonuclear leukocytes in ulcerative colitis. An electron-microscopic study.溃疡性结肠炎中的结肠上皮细胞和多形核白细胞。一项电子显微镜研究。
Am J Dig Dis. 1975 Mar;20(3):236-52. doi: 10.1007/BF01070727.
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[Morphofunctional changes in large-intestinal mucosa in nonspecific ulcerative colitis].[非特异性溃疡性结肠炎大肠黏膜的形态功能变化]
Vrach Delo. 1985 Mar(3):73-6.
6
[Comparative electron microscopy study of the stages of ulcerative colitis. I. Changes in the epithelial cells].溃疡性结肠炎各阶段的比较电子显微镜研究。I. 上皮细胞的变化
Morphol Igazsagugyi Orv Sz. 1988 Apr;28(2):85-93.
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[Forward-morphological criteria of ulcerative colitis relapse and continuous flow in children].[儿童溃疡性结肠炎复发和持续进展的正向形态学标准]
Vestn Ross Akad Med Nauk. 2013(10):32-6.
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[Evaluation of the healing of ulcerative colitis by colonic gland density].[通过结肠腺密度评估溃疡性结肠炎的愈合情况]
Nihon Shokakibyo Gakkai Zasshi. 1984 Jun;81(6):1377-87.
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Scanning electron microscopic appearance of chronic ulcerative colitis with and without dysplasia.
Gastroenterology. 1985 Jul;89(1):62-72. doi: 10.1016/0016-5085(85)90746-2.
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Severe eosinophilic infiltration in colonic biopsies predicts patients with ulcerative colitis not responding to medical therapy.结肠活检中严重嗜酸性粒细胞浸润预示溃疡性结肠炎患者对药物治疗无反应。
Colorectal Dis. 2014 Dec;16(12):O420-30. doi: 10.1111/codi.12725.

引用本文的文献

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Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis.抑制中性粒细胞弹性蛋白酶可预防小鼠硫酸葡聚糖钠诱导的结肠炎的发展。
J Gastroenterol. 2006 Apr;41(4):318-24. doi: 10.1007/s00535-005-1768-8.
2
A new chronic ulcerative colitis model produced by combined methods in rats.一种采用联合方法建立的大鼠慢性溃疡性结肠炎新模型。
World J Gastroenterol. 2000 Oct;6(5):742-746. doi: 10.3748/wjg.v6.i5.742.
3
A new hypothesis for the aetiology of Crohn's disease--evidence from lipid metabolism and intestinal tuberculosis.
克罗恩病病因学的新假说——来自脂质代谢和肠结核的证据
Postgrad Med J. 1991 Jul;67(789):666-71. doi: 10.1136/pgmj.67.789.666.