Dobbins W O
Am J Dig Dis. 1975 Mar;20(3):236-52. doi: 10.1007/BF01070727.
The following study cinfirms previously reported electron-microscopic findings in ulcerative colitis and agrees with the nonspecific nature of those findings. The study extends these observations in regard to relationship of PMN leukocytes, eosinophil leukocytes, and mast cells to colonic epithelial cells. Strong, though not conclusive, data that PMN and eosinophil leukocytes extensively invade epithelial cells in ulcerative colitis is presented. This finding also is not specific to ulcerative colitis and was found with much less frequency in Crohn's disease of the colon and in salmonella colitis. The presence of intravascular degranulation of PMN leukocytes in ulcerative colitis is confirmed. This study adds additional support to the concept that the major abnormality in ulcerative colitis resides within the colonic epithelial cell.
以下研究证实了先前报道的溃疡性结肠炎的电子显微镜检查结果，并认同这些结果的非特异性。该研究就中性粒细胞、嗜酸性粒细胞和肥大细胞与结肠上皮细胞的关系扩展了这些观察结果。提供了有力但非结论性的数据，表明在溃疡性结肠炎中中性粒细胞和嗜酸性粒细胞广泛侵入上皮细胞。这一发现也并非溃疡性结肠炎所特有，在结肠克罗恩病和沙门氏菌结肠炎中出现的频率要低得多。溃疡性结肠炎中中性粒细胞血管内脱颗粒的存在得到了证实。这项研究进一步支持了溃疡性结肠炎的主要异常存在于结肠上皮细胞内的观点。
