Traditional Medicine Faculty, Tabriz university of Medical Sciences, Tabriz, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Complement Ther Clin Pract. 2018 May;31:352-359. doi: 10.1016/j.ctcp.2017.12.001. Epub 2017 Dec 6.
Leech saliva extract (LSE) in the liposome-based gel was used as a supplementary treatment to relief the signs and symptoms of osteoarthritis (OA). The saliva of medical leech was extracted and nano liposomes were used to formulate the supplement to enhance skin absorption. A clinical trial was designed to evaluate the therapeutic effects of LSE liposomal gel. Lenquesne and VAS questionnaires were used as indexes of this supplement therapy efficacy for 30 days. Questionnaires analysis showed that after one-month administration of LSE liposomal gel, patients' pain was relieved approximately up to 50%; also, due to reduction in joint inflammation and stiffness, the range of motion was increased and the patients' quality of life was enhanced (p < 0.001). LSE nano scaled liposomal gel as an innovative supplement therapy in OA patients, makes desirable therapeutic approach, which seems to make a significant impact on patient's quality of life and self-care capability.
以水蛭唾液提取物（LSE）为基础的脂质体凝胶被用作补充治疗方法，以缓解骨关节炎（OA）的症状和体征。从医用水蛭中提取唾液，并使用纳米脂质体来配制该补充剂以增强皮肤吸收。设计了一项临床试验来评估 LSE 脂质体凝胶的治疗效果。Lenquesne 和 VAS 问卷被用作该补充治疗功效的指标，为期 30 天。问卷分析表明，在使用 LSE 脂质体凝胶一个月后，患者的疼痛缓解了大约 50％；此外，由于关节炎症和僵硬的减轻，运动范围增加，患者的生活质量得到了提高（p <0.001）。作为 OA 患者的创新补充治疗方法，LSE 纳米级脂质体凝胶提供了理想的治疗方法，似乎对患者的生活质量和自我护理能力产生了重大影响。
