Faculty of Health and Sport Science, University of Tsukuba, Tsukuba, Japan.
Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
PLoS One. 2018 Mar 20;13(3):e0194572. doi: 10.1371/journal.pone.0194572. eCollection 2018.
Maslinic acid (MA) is a component derived from a natural olive-based extract known to have pharmacological functions that include suppressing inflammation. This study examined how MA, in conjunction with whole-body vibration training (WBVT), can improve knee and muscle function in elderly women with knee osteoarthritis (OA).
The study was a double-blinded, placebo-controlled, randomized intervention study that enrolled individuals with knee pain. Participants were 26 females aged 65-85 years with knee OA. They performed WBVT and ingested either 16.7 mg of MA or a placebo daily for 20 weeks. We compared the effect of WBVT with placebo (WBVT/P) and WBVT with MA (WBVT/MA) in participants with various degrees of knee OA (Kellgren and Lawrence (K-L) grade) using the Japanese Orthopaedic Association (JOA) score and isokinetic dynamometer measurements to evaluate knee and muscle function with two-way ANOVA.
Based on the results of two-way ANOVA analysis of muscle function measurements, there was significant interaction (time × group) (P = 0.03) in the "isokinetic extension peak torque" domain for severe OA (K-L grade ≥ 3). The simple main effect of time in the WBVT/MA group (P = 0.04) contributed to this interaction. The JOA score for WBVT/MA supported the main effect of group as having a significant correlation in the "pain on walking" (P = 0.04) and "range of motion" (P < 0.01) domains. Participants with severe knee OA in the WBVT/MA group improved in these domains, whereas the WBVT/P group had few positive results.
Participants with severe OA who ingested MA in conjunction with WBVT improved their knee and muscle function. This study suggests that ingesting the anti-inflammatory supplement MA while participating in WBVT, elderly women can reduce knee OA and improve their knee muscle strength.
马尿酸（MA）是一种源自天然橄榄油提取物的成分，具有药理学功能，包括抑制炎症。本研究探讨了 MA 与全身振动训练（WBVT）联合使用如何改善老年膝骨关节炎（OA）女性的膝关节和肌肉功能。
这是一项双盲、安慰剂对照、随机干预研究，纳入了有膝关节疼痛的个体。参与者为 26 名年龄在 65-85 岁之间、患有膝骨关节炎的女性。她们接受 WBVT 并每天服用 16.7 毫克 MA 或安慰剂，持续 20 周。我们使用日本骨科协会（JOA）评分和等速测力计测量来比较 WBVT 与安慰剂（WBVT/P）和 WBVT 与 MA（WBVT/MA）对不同程度膝骨关节炎（Kellgren 和劳伦斯（K-L）分级）患者的影响，并进行双向方差分析。
基于肌肉功能测量的双向方差分析结果，在严重 OA（K-L 分级≥3）的“等速伸肌峰值扭矩”域中存在显著的交互作用（时间×组）（P=0.03）。WBVT/MA 组的时间简单主效应（P=0.04）促成了这种相互作用。WBVT/MA 的 JOA 评分支持组的主要作用，在“步行疼痛”（P=0.04）和“关节活动度”（P<0.01）域中具有显著相关性。在 WBVT/MA 组中，严重膝关节 OA 的患者在这些领域得到了改善，而 WBVT/P 组的积极结果较少。
服用 MA 与 WBVT 联合治疗的严重 OA 患者改善了膝关节和肌肉功能。本研究表明，老年女性在接受 WBVT 的同时服用抗炎补充剂 MA，可以减轻膝骨关节炎并改善膝关节肌肉力量。
