Rasokat H, Bendick C, Wemmer U, Steigleder G K
Universitäts-Hautklinik, Köln.
Dtsch Med Wochenschr. 1989 Mar 24;114(12):458-60. doi: 10.1055/s-2008-1066618.
Aseptic necrosis of the skin developed in two patients with HIV-associated disseminated Kaposi's sarcoma after subcutaneous injection of recombinant interferon-alpha. Both patients were given it at a daily dosage of 20 x 10(6) IU/m2 body surface area. One of the patients, after full remission had been achieved, received a reduced dosage of 3 x 10(6) IU/m2, twice weekly. The clinical picture and course of the changes were similar to those of embolia cutis medicamentosa (Nicolau's syndrome), which can occur after injection of various drugs, intended to be intramuscular but by mistake given intra-arterially.
两名患有人类免疫缺陷病毒（HIV）相关播散性卡波西肉瘤的患者在皮下注射重组干扰素α后出现了皮肤无菌性坏死。两名患者均按20×10⁶国际单位/平方米体表面积的每日剂量给药。其中一名患者在完全缓解后，接受了3×10⁶国际单位/平方米的减量剂量，每周两次。临床表现和变化过程与药物性皮肤栓塞（尼科劳综合征）相似，后者可在注射各种本应肌内注射但误作动脉内注射的药物后发生。
