Plastic and Reconstructive Surgery, Campus Bio-Medico di Roma University, Rome, Italy.
J Dermatol. 2010 May;37(5):488-92. doi: 10.1111/j.1346-8138.2010.00864.x.
Embolia cutis medicamentosa, also known as Nicolau's syndrome, is a rare complication due to i.m. injections. Its real incidence is actually underestimated. Many drugs have been associated with it, but at the time only a few studies showed a related pathogenetic mechanism. Symptoms consist of immediate local pain, edema and cutaneous, subcutaneous and even muscular necrosis occurring in the first 48 h. The type of treatment depends mostly on time of diagnosis. A medical resolution can be achieved through heparin and cortisone injections within the first 48 h. Surgical debridement has to be considered as the main treatment in case of late diagnosis. We present three cases of Nicolau's syndrome presenting to us in a short period of time that we treated with surgical debridement.
药物性皮肤栓塞，也称为尼科劳综合征，是一种罕见的因肌肉注射引起的并发症。它的实际发病率实际上被低估了。许多药物都与它有关，但当时只有少数研究显示出相关的发病机制。症状包括在最初的 48 小时内立即出现局部疼痛、水肿和皮肤、皮下甚至肌肉坏死。治疗类型主要取决于诊断时间。在最初的 48 小时内，通过肝素和皮质类固醇注射可以实现医疗解决。如果诊断较晚，则需要考虑手术清创作为主要治疗方法。我们在短时间内治疗了 3 例尼科劳综合征患者，均采用手术清创。
