Aranegui B, Jiménez-Reyes J
Servicio de Dermatología, Hospital Universitario Infanta Cristina , Parla, Madrid, España.
Servicio de Dermatología, Hospital Universitario Infanta Cristina , Parla, Madrid, España.
Actas Dermosifiliogr (Engl Ed). 2018 May;109(4):312-322. doi: 10.1016/j.ad.2017.06.021. Epub 2017 Dec 14.
Morphea is an inflammatory, fibrosing skin disorder. When it occurs in childhood, it is also known as localized juvenile scleroderma. It is more common in girls and typically appears around the age of 5 to 7 years. According to a recent classification system, morphea is divided into 5 types: circumscribed (plaque), linear, generalized, pansclerotic, and mixed. Approximately 40% of patients present extracutaneous manifestations. Childhood morphea is treated with phototherapy, oral or topical calcitriol, topical tacrolimus 0.1%, methotrexate, topical or systemic corticosteroids, mycophenolate mofetil, bosentán, and topical imiquimod 5%. A variety of measuring tools are used to monitor response to treatment. Few prognostic studies have been conducted, but findings to date suggest that the disease tends to run a chronic or intermittent-recurrent course and frequently causes sequelae.
硬斑病是一种炎症性、纤维化性皮肤病。当它发生在儿童期时，也被称为局限性幼年硬皮病。它在女孩中更常见，通常出现在5至7岁左右。根据最近的分类系统，硬斑病分为5种类型：局限性（斑块状）、线状、全身性、泛硬化性和混合型。约40%的患者会出现皮肤外表现。儿童硬斑病的治疗方法包括光疗、口服或外用骨化三醇、0.1%外用他克莫司、甲氨蝶呤、外用或全身性皮质类固醇、霉酚酸酯、波生坦以及5%外用咪喹莫特。使用多种测量工具来监测治疗反应。很少有预后研究，但迄今为止的研究结果表明，该病往往呈慢性或间歇性复发病程，并经常导致后遗症。
