Bielsa Marsol I
Servicio de Dermatología, Hospital Universitari Germans Trias i Pujol, Universidad Autónoma de Barcelona, Barcelona, Spain.
Actas Dermosifiliogr. 2013 Oct;104(8):654-66. doi: 10.1016/j.adengl.2012.10.012. Epub 2013 Aug 13.
Morphea or localized scleroderma is a distinctive inflammatory disease that leads to sclerosis of the skin and subcutaneous tissues. It comprises a number of subtypes differentiated according to their clinical presentation and the structure of the skin and underlying tissues involved in the fibrotic process. However, classification is difficult because the boundaries between the different types of morphea are blurred and different entities frequently overlap. The main subtypes are plaque morphea, linear scleroderma, generalized morphea, and pansclerotic morphea. With certain exceptions, the disorder does not have serious systemic repercussions, but it can cause considerable morbidity. In the case of lesions affecting the head, neurological and ocular complications may occur. There is no really effective and universal treatment so it is important to make a correct assessment of the extent and severity of the disease before deciding on a treatment approach.
硬斑病或局限性硬皮病是一种独特的炎症性疾病，可导致皮肤和皮下组织硬化。它包括多种亚型，根据临床表现以及参与纤维化过程的皮肤和深层组织的结构进行区分。然而，分类很困难，因为不同类型硬斑病之间的界限模糊，不同实体常常相互重叠。主要亚型有斑块状硬斑病、线状硬皮病、泛发性硬斑病和全硬化性硬斑病。除某些例外情况，该疾病不会产生严重的全身性影响，但会导致相当大的发病率。在病变累及头部的情况下，可能会出现神经和眼部并发症。目前没有真正有效且通用的治疗方法，因此在决定治疗方案之前，正确评估疾病的范围和严重程度非常重要。
