Department of Basic Sciences, Erzurum Technical University, Faculty of Science, Erzurum, Turkey.
Department of Basic Sciences, Erzurum Technical University, Faculty of Science, Erzurum, Turkey.
Arch Med Res. 2017 Aug;48(6):513-519. doi: 10.1016/j.arcmed.2017.12.002. Epub 2017 Dec 14.
In the present study, a series of ureas and sulfamides derived from 1-aminotetralins were synthesized. For this purpose, urea and sulfamide analogues were synthesized from the reactions of substituted 1-aminotetralins with N,N-dimethylcarbamoyl chloride and N,N-dimethylsulfamoyl chloride. The anticancer activity of newly synthesized compounds was tested against human U-87MG glioblastoma and PC-3 prostate cancer cell lines. Cytotoxicity was examined using MTT and LDH release assays.
The obtained data revealed that tested compounds showed a variable degree of cytotoxic activity against the tested cell lines. 3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-1,1-dimethylurea (9) and 3-(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-1,1-dimethylurea (10) proved to be the most active cytotoxic members in this study.
These two compounds could be considered as possible anticancer agents.
在本研究中，我们合成了一系列衍生自 1-氨基四氢萘的脲和磺酰胺类化合物。为此，我们通过取代的 1-氨基四氢萘与 N,N-二甲基氨基甲酰氯和 N,N-二甲基磺酰胺酰氯的反应合成了脲和磺酰胺类似物。我们测试了新合成化合物对人 U-87MG 神经胶质瘤和 PC-3 前列腺癌细胞系的抗癌活性。使用 MTT 和 LDH 释放测定法检测细胞毒性。
获得的数据表明，测试的化合物对测试的细胞系表现出不同程度的细胞毒性活性。3-(5-甲氧基-1,2,3,4-四氢萘-1-基）-1,1-二甲基脲（9）和 3-(6-甲氧基-1,2,3,4-四氢萘-1-基）-1,1-二甲基脲（10）被证明是本研究中最具活性的细胞毒性成员。
这两种化合物可以被认为是有希望的抗癌药物。
