Dwyer B E, Nishimura R N, Brown I R
Epilepsy Research Laboratory, VA Medical Center, Sepulveda, California 91343.
Exp Neurol. 1989 Apr;104(1):28-31. doi: 10.1016/0014-4886(89)90005-8.
Rats aged 7 days were exposed to 3.5 h of cerebral hypoxia-ischemia produced by unilateral common carotid artery ligation combined with hypoxia (8% oxygen). The major inducible heat-shock protein, HSP-68, was synthesized in ipsilateral but not contralateral (control) hippocampus during early recovery (1 and 3 h). HSP-68 synthesis was not detected during longer recovery periods. The presence of HSP-68 was confirmed by Western blotting and immunostaining with a polyclonal antibody to HSP-68.
