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脑血管自动调节功能对尼莫地平的钙通道阻滞作用具有抗性。

Cerebrovascular autoregulation is resistant to calcium channel blockade with nimodipine.

作者信息

McCalden T A, Nath R G

机构信息

Cerebrovascular Research Laboratory, VA Medical Center, Houston, Texas.

出版信息

Experientia. 1989 Mar 15;45(3):305-6. doi: 10.1007/BF01951818.

DOI:10.1007/BF01951818
PMID:2924880
Abstract

In normal baboons cerebrovascular resistance changed along with blood pressure to maintain blood flow constant. This 'autoregulation' was not significantly altered in animals treated with a dose of the calcium channel blocker nimodipine causing selective cerebral vasodilation.

摘要

在正常狒狒中，脑血管阻力随血压变化以维持血流恒定。在用导致选择性脑血管扩张的钙通道阻滞剂尼莫地平治疗的动物中，这种“自动调节”没有明显改变。

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Cerebrovascular autoregulation is resistant to calcium channel blockade with nimodipine.脑血管自动调节功能对尼莫地平的钙通道阻滞作用具有抗性。
Experientia. 1989 Mar 15;45(3):305-6. doi: 10.1007/BF01951818.
2
Autoregulation of cerebral blood flow during calcium channel blockade with nimodipine.尼莫地平钙通道阻滞期间脑血流的自动调节
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3
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J Pharmacol Exp Ther. 1986 Apr;237(1):36-9.
4
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J Neurosurg Anesthesiol. 1994 Apr;6(2):116-21. doi: 10.1097/00008506-199404000-00007.
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Calcium antagonists for aneurysmal subarachnoid haemorrhage.用于动脉瘤性蛛网膜下腔出血的钙拮抗剂。

本文引用的文献

1
Effect of the calcium antagonist, nimodipine, on cerebral blood flow and metabolism in the primate.钙拮抗剂尼莫地平对灵长类动物脑血流和代谢的影响。
J Cereb Blood Flow Metab. 1981;1(3):349-56. doi: 10.1038/jcbfm.1981.38.
2
Sources of activator calcium in rabbit basilar artery.兔基底动脉中激活钙的来源。
Am J Physiol. 1981 Aug;241(2):H129-33. doi: 10.1152/ajpheart.1981.241.2.H129.
3
Late cerebral arterial spasm: the cerebrovascular response to hypercapnia, induced hypertension and the effect of nimodipine on blood flow autoregulation in experimental subarachnoid hemorrhage in primates.
Cochrane Database Syst Rev. 2007 Jul 18;2007(3):CD000277. doi: 10.1002/14651858.CD000277.pub3.
4
The effect of nimodipine on autoregulation of cerebral blood flow after subarachnoid haemorrhage in rat.尼莫地平对大鼠蛛网膜下腔出血后脑血流自动调节的影响。
Acta Neurochir (Wien). 1995;132(1-3):98-103. doi: 10.1007/BF01404855.
迟发性脑动脉痉挛：灵长类动物实验性蛛网膜下腔出血中脑血管对高碳酸血症、诱导性高血压的反应以及尼莫地平对血流自动调节的影响。
Gen Pharmacol. 1983;14(1):167-72. doi: 10.1016/0306-3623(83)90093-9.
4
Effect of Ca-antagonists on the contraction of cerebral and peripheral arteries produced by electrical and mechanical stimuli.钙拮抗剂对电刺激和机械刺激所引起的脑动脉及外周动脉收缩的影响。
Gen Pharmacol. 1983;14(1):111-3. doi: 10.1016/0306-3623(83)90076-9.
5
The effects of a calcium antagonist, nimodipine, upon physiological responses of the cerebral vasculature and its possible influence upon focal cerebral ischaemia.钙拮抗剂尼莫地平对脑血管生理反应的影响及其对局灶性脑缺血的可能影响。
Stroke. 1982 Nov-Dec;13(6):759-66. doi: 10.1161/01.str.13.6.759.
6
Effect of the calcium antagonist nimodipine on local cerebral blood flow: relationship to arterial blood pressure.钙拮抗剂尼莫地平对局部脑血流量的影响：与动脉血压的关系。
J Cereb Blood Flow Metab. 1984 Jun;4(2):206-11. doi: 10.1038/jcbfm.1984.29.
7
Factors involved in the physiological regulation of the cerebral circulation.
Rev Physiol Biochem Pharmacol. 1984;101:161-211. doi: 10.1007/BFb0027696.
8
Effects of nimodipine on cerebral vasoconstrictor responses.
Am J Physiol. 1984 Aug;247(2 Pt 2):H170-6. doi: 10.1152/ajpheart.1984.247.2.H170.
9
The effects of a calcium antagonist (nimodipine) on basal cerebral blood flow and reactivity to various agonists.
Stroke. 1984 May-Jun;15(3):527-30. doi: 10.1161/01.str.15.3.527.
10
Regulation of cerebral circulation.脑循环的调节
Sci Basis Med Annu Rev. 1969:60-81.