Mohamed A A, McCulloch J, Mendelow A D, Teasdale G M, Harper A M
J Cereb Blood Flow Metab. 1984 Jun;4(2):206-11. doi: 10.1038/jcbfm.1984.29.
The effect of the calcium antagonist nimodipine on local CBF in 31 regions of the CNS was studied with the [14C]iodoantipyrine autoradiographic technique in lightly anaesthetised, mechanically ventilated rats. Continuous intravenous infusion of nimodipine (1, 2, or 4 micrograms kg-1 min-1) produced a dose-dependent reduction in MABP (reduced by 26 +/- 2% after 30 min of nimodipine, 4 micrograms kg-1 min-1) and a significant elevation in plasma glucose concentration (increased by 44 +/- 2% after 30 min of nimodipine, 4 micrograms kg-1 min-1). Local CBF was increased significantly during infusions of nimodipine (1 microgram kg-1 min-1) in 9 of the 31 regions examined (including the cerebral cortex, hippocampus, hypothalamus, and most thalamic nuclei). In contrast to the increases in CBF observed in forebrain regions, no significant increases in CBF were observed during nimodipine infusions in regions of the lower brainstem, cerebellum, and pons or in myelinated fibre tracts. The proportionately greatest increases in local CBF were observed during infusions of the lowest dosage of nimodipine (1 microgram kg-1 min-1), suggesting either that this dosage provokes maximum cerebrovascular relaxation or that effects of increasing concentrations are counteracted by the concomitant systemic hypotension.
采用[¹⁴C]碘安替比林放射自显影技术，在轻度麻醉、机械通气的大鼠中研究了钙拮抗剂尼莫地平对中枢神经系统31个区域局部脑血流量（CBF）的影响。持续静脉输注尼莫地平（1、2或4微克·千克⁻¹·分钟⁻¹）导致平均动脉血压（MABP）呈剂量依赖性降低（尼莫地平4微克·千克⁻¹·分钟⁻¹输注30分钟后降低26±2%），并使血浆葡萄糖浓度显著升高（尼莫地平4微克·千克⁻¹·分钟⁻¹输注30分钟后升高44±2%）。在输注尼莫地平（1微克·千克⁻¹·分钟⁻¹）期间，在所检查的31个区域中的9个区域（包括大脑皮层、海马体、下丘脑和大多数丘脑核）局部CBF显著增加。与在前脑区域观察到的CBF增加相反，在尼莫地平输注期间，在脑桥下部、小脑和脑桥区域或有髓纤维束中未观察到CBF显著增加。在输注最低剂量的尼莫地平（1微克·千克⁻¹·分钟⁻¹）期间观察到局部CBF增加的比例最大，这表明该剂量可引起最大程度的脑血管舒张，或者浓度增加的影响被伴随的全身性低血压所抵消。
