多发性骨髓瘤和单克隆丙种球蛋白病中的唾液酸转移酶活性和唾液酸水平

Sialyltransferase activity and sialic acid levels in multiple myeloma and monoclonal gammopathy.

作者信息

Cohen A M, Allalouf D, Bessler H, Djaldetti M, Malachi T, Levinsky H

机构信息

Hematology Clinic, Golda Medical Center, Petah-Tikva, Israel.

出版信息

Eur J Haematol. 1989 Mar;42(3):289-92. doi: 10.1111/j.1600-0609.1989.tb00114.x.

DOI:10.1111/j.1600-0609.1989.tb00114.x

PMID:2924892

Abstract

A significant elevation of peripheral blood mononuclear cell sialyltransferase activity (STA) was observed in 14 patients with multiple myeloma (MM), and compared to 7 patients with monoclonal gammopathy of undetermined significance (MGUS) and to 10 controls. Serum sialyltransferase was significant higher in MM patients as compared to controls. It was also higher than in MGUS patients, but the difference here was not statistically significant. STA was also determined in mononuclear bone marrow cells of 5 patients with MM (with 50 to 100% plasma cells in the bone marrow aspirate) and found to be 19 times higher than that of bone marrow mononuclear cells from 6 patients with non-malignant disorders (with less than 1% plasma cells in the bone marrow aspirate). No significant differences were observed in peripheral blood mononuclear cell sialic acid levels between MM, MGUS and controls.

摘要

在14例多发性骨髓瘤（MM）患者中观察到外周血单核细胞唾液酸转移酶活性（STA）显著升高，并与7例意义未明的单克隆丙种球蛋白病（MGUS）患者及10名对照进行比较。与对照相比，MM患者的血清唾液酸转移酶显著更高。其也高于MGUS患者，但此处差异无统计学意义。还测定了5例MM患者（骨髓穿刺液中浆细胞占50%至100%）骨髓单核细胞中的STA，发现其比6例非恶性疾病患者（骨髓穿刺液中浆细胞少于1%）骨髓单核细胞中的STA高19倍。MM、MGUS和对照之间在外周血单核细胞唾液酸水平上未观察到显著差异。