多发性骨髓瘤浆细胞中的唾液酸转移酶活性

Sialyltransferase activity in plasma cells of multiple myeloma.

作者信息

Cohen A M, Allalouf D, Djaldetti M, Weigl K, Lehrer N, Levinsky H

机构信息

Hematology Clinic, Sackler School of Medicine, Tel-Aviv University, Israel.

出版信息

Eur J Haematol. 1989 Sep;43(3):191-4. doi: 10.1111/j.1600-0609.1989.tb00281.x.

DOI:10.1111/j.1600-0609.1989.tb00281.x

PMID:2806473

Abstract

A marked elevation of sialyltransferase activity (STA) was observed in a solid tumor of plasma cells, which had been removed from a patient with multiple myeloma (MM), as compared to normal lymphatic tissues. STA was also determined in mononuclear bone marrow cells of 10 patients with MM and found to be 12 times higher than that of bone marrow mononuclear cells from 5 patients with non-malignant disorders (with less than 1% plasma cells in the bone marrow aspirate). A significant correlation was found between STA and the number of plasma cells in the bone marrow aspirate.

摘要

与正常淋巴组织相比，在一名患有多发性骨髓瘤（MM）的患者体内切除的浆细胞实体瘤中观察到唾液酸转移酶活性（STA）显著升高。还对10例MM患者的单核骨髓细胞进行了STA测定，发现其比5例非恶性疾病患者（骨髓穿刺液中浆细胞少于1%）的骨髓单核细胞高12倍。STA与骨髓穿刺液中浆细胞数量之间存在显著相关性。