Bode S A, Löwik D W P M
Radboud University Nijmegen, Institute for Molecules and Materials, Bio-organic Chemistry, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Radboud University Nijmegen, Institute for Molecules and Materials, Bio-organic Chemistry, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Drug Discov Today Technol. 2017 Dec;26:33-42. doi: 10.1016/j.ddtec.2017.11.005. Epub 2017 Nov 27.
In this review we provide an overview of recent developments in the field of cell penetrating peptides (CPPs) on research that aims to achieve better control over their transduction properties - one of the big challenges - by means of restraining them. Three different constraining strategies are presented: triggerable activation, backbone rigidification and macrocyclization. Each of these methods have their opportunities in gaining control over CPP activity and selectivity.
在本综述中，我们概述了细胞穿透肽（CPPs）领域的最新进展，这些研究旨在通过限制细胞穿透肽来更好地控制其转导特性，这是一项重大挑战。本文介绍了三种不同的限制策略：可触发激活、主链刚性化和大环化。这些方法中的每一种在控制CPP活性和选择性方面都有其机会。
