Davis O K, Berkeley A S, Naus G J, Cholst I N, Freedman K S
Department of Obstetrics and Gynecology, New York Hospital-Cornell Medical Center, New York, New York.
Fertil Steril. 1989 Apr;51(4):582-6. doi: 10.1016/s0015-0282(16)60603-9.
Five regularly menstruating women of proven fertility, with normal prolactin and thyroid function studies, underwent a total of 39 endometrial biopsies (EMBs). The slides were dated in blinded fashion, and the cycle date determined by considering the date of the next menstrual period as day 28 and counting backward. Using a 2-day or greater lag in endometrial maturity to define a luteal phase defect (LPD), the incidence of single and sequential out-of-phase EMBs was 51.4% and 26.7%, respectively. Using a 3-day or greater lag to define a LPD, the incidence of single and sequential out-of-phase EMBs was 31.4% and 6.6%, respectively. These incidences in normal, fertile women are as high as the rates quoted for infertile populations, and call into question the standard criteria for defining this condition and evaluating therapies to correct it.
五名月经周期规律、生育能力已得到证实且催乳素和甲状腺功能检查正常的女性，共接受了39次子宫内膜活检（EMB）。玻片以盲法标注日期，通过将下次月经日期视为第28天并倒推来确定周期日期。以子宫内膜成熟延迟2天或更长时间来定义黄体期缺陷（LPD），单次和连续不同步EMB的发生率分别为51.4%和26.7%。以延迟3天或更长时间来定义LPD，单次和连续不同步EMB的发生率分别为31.4%和6.6%。正常、有生育能力女性中的这些发生率与不育人群所引用的比率一样高，这让人对定义这种情况以及评估纠正它的疗法的标准准则产生质疑。
