Noci I, Dubini V, Piacentini R, Colafranceschi M, Taddei G, Scarselli G
Department di Ostetricia e Ginecologia, University of Firenze, Italy.
J Endocrinol Invest. 1988 May;11(5):361-3. doi: 10.1007/BF03349055.
One hundred forty-three women complaining for couple infertility (more than 2 yr), were investigated for luteal phase deficiency (i.e. insufficient endometrial luteinization) by endometrial biopsy and serial determinations (in days -10, -7 and -4 respect the onset of the next menses) of plasma progesterone during luteal phase. One hundred-three women had the first endometrial biopsy in phase (IP), 36 had the biopsy "out of phase" (OOP). Among them 13 did not repeat endometrial biopsy, 12 had the second biopsy out of phase (and then classified as Luteal Phase Deficiency) and 11 had the second biopsy "in phase". Only the women affected by luteal phase deficiency had the plasma progesterone (mean of 3 samples) significantly lower than that of infertile women with normal endometrial luteinization. However the majority of the individual progesterone values of these two groups overlapped. The endometrial biopsy seems to be the most practicable method for investigating luteal phase deficiency in women complaining for couple infertility.
143名因夫妻不孕（超过2年）前来就诊的女性，通过子宫内膜活检以及在黄体期（相对于下次月经来潮分别为第-10、-7和-4天）连续测定血浆孕酮，来研究黄体期缺陷（即子宫内膜黄体化不足）。103名女性首次子宫内膜活检处于期内（IP），36名女性活检“不在期内”（OOP）。其中13名未重复进行子宫内膜活检，12名第二次活检不在期内（随后归类为黄体期缺陷），11名第二次活检“在期内”。只有受黄体期缺陷影响的女性其血浆孕酮（3次样本均值）显著低于子宫内膜黄体化正常的不孕女性。然而，这两组的大多数个体孕酮值有重叠。对于因夫妻不孕前来就诊的女性，子宫内膜活检似乎是研究黄体期缺陷最可行的方法。
