The Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health; The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China; Department of Cardiology, Shandong Provincial Chest Hospital, Jinan, China.
The Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health; The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Arch Med Res. 2017 Aug;48(6):526-534. doi: 10.1016/j.arcmed.2017.12.003. Epub 2017 Dec 14.
Cyclophilin A (CyPA) is an abundantly expressed pro-inflammatory cytokine and a major secreted oxidative stress-induced factor (SOXF). Melatonin is an important chronobiological regulatory molecule that is mainly released from the pineal gland and exerts antioxidant effects by acting as a radical scavenger. Based on accumulating evidence, both CyPA and melatonin play important roles in cardiovascular diseases. However, further investigations are required to determine whether CyPA and melatonin are associated with hypertension-induced left ventricular hypertrophy (LVH).
A total of 135 patients with essential hypertension were divided into an LVH (+) group and an LVH (-) group according to Doppler echocardiography results. Clinical data of the two groups were evaluated.
High CyPA levels and low melatonin levels are independent risk factors for LVH (p = 0.000). In addition, body mass index (BMI) and systolic blood pressure (SBP) are correlated with the risk of LVH (p = 0.000). However, other factors did not display statistically significant associations (p >0.05). The Pearson correlation and linear regression analyses show that BMI, SBP, and CyPA levels were positively correlated with left ventricular mass (LVM) and the left ventricular mass index (LVMI) (p <0.05), whereas melatonin levels were negatively correlated with LVM and the LVMI (p = 0.000). Furthermore, according to the results of the Pearson correlation analysis, CyPA levels were negatively correlated with melatonin levels (p <0.01) in subjects with LVH.
Based on these results, both CyPA and melatonin are closely related to the pathogenesis of LVH. As CyPA was negatively correlated with melatonin in patients with LVH, additional studies are required to determine whether melatonin may partially protect the myocardium by decreasing CyPA levels.
亲环素 A（CyPA）是一种丰富表达的促炎细胞因子，也是主要的氧化应激诱导因子（SOXF）。褪黑素是一种重要的生物钟调节分子，主要由松果体分泌，通过充当自由基清除剂发挥抗氧化作用。基于越来越多的证据，CyPA 和褪黑素在心血管疾病中都发挥着重要作用。然而，还需要进一步的研究来确定 CyPA 和褪黑素是否与高血压引起的左心室肥厚（LVH）有关。
根据多普勒超声心动图结果，将 135 例原发性高血压患者分为左心室肥厚（LVH）阳性组和左心室肥厚（LVH）阴性组。评估两组的临床资料。
高水平的 CyPA 和低水平的褪黑素是 LVH 的独立危险因素（p=0.000）。此外，体重指数（BMI）和收缩压（SBP）与 LVH 的风险相关（p=0.000）。然而，其他因素没有显示出统计学上的显著相关性（p>0.05）。Pearson 相关和线性回归分析显示，BMI、SBP 和 CyPA 水平与左心室质量（LVM）和左心室质量指数（LVMI）呈正相关（p<0.05），而褪黑素水平与 LVM 和 LVMI 呈负相关（p=0.000）。此外，根据 Pearson 相关分析的结果，LVH 患者 CyPA 水平与褪黑素水平呈负相关（p<0.01）。
基于这些结果，CyPA 和褪黑素都与 LVH 的发病机制密切相关。由于 CyPA 与 LVH 患者的褪黑素呈负相关，还需要进一步的研究来确定褪黑素是否可以通过降低 CyPA 水平来部分保护心肌。
