原发性高血压患者同型半胱氨酸、血压变异性与左心室肥厚的关系：一项观察性研究。
The Relationship Between Homocysteine, Blood Pressure Variability, and Left Ventricular Hypertrophy in Patients with Essential Hypertension: An Observational Study.
机构信息
Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University & Guangxi Key Laboratory Base of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention and Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases, Nanning, 530021, China.
Department of Cardiology, The Sixth Affiliated Hospital, Guangxi Medical University, Yulin, 537000, China.
出版信息
Adv Ther. 2020 Jan;37(1):381-389. doi: 10.1007/s12325-019-01154-7. Epub 2019 Nov 21.
INTRODUCTION
This study aimed to investigate the relationship between homocysteine (Hcy) and blood pressure variability (BPV) and the relationship between Hcy and left ventricular hypertrophy (LVH) in 102 patients with essential hypertension.
METHODS
The 102 patients were divided into the Hcy < 10 μmol/L group (n = 47) and the Hcy ≥ 10 μmol/L group (n = 55) according to Hcy concentration. The differences between Hcy and BPV and Hcy and LVH were compared between the two groups. Finally, the correlations between Hcy and BPV and between Hcy and LVH were analyzed.
RESULTS
The results showed that there were significant differences between Hcy and BPV and between Hcy and LVH in the two groups. Hcy correlated positively with the coefficient of variation in nighttime diastolic blood pressure and night systolic blood pressure standard deviation (nDBPSD), with correlation coefficients of 0.331 and 0.303 (P < 0.001). At the same time, Hcy correlated positively with interventricular septal thickness and left ventricular posterior wall thickness, which were indicators of LVH, with correlation coefficients of 0.350 and 0.352 (P < 0.001).
CONCLUSIONS
There was a correlation between Hcy and BPV and between Hcy and LVH. Attention should also be paid to blood Hcy and BPV for patients with essential hypertension.
简介
本研究旨在探讨 102 例原发性高血压患者同型半胱氨酸（Hcy）与血压变异性（BPV）之间的关系，以及 Hcy 与左心室肥厚（LVH）之间的关系。
方法
根据 Hcy 浓度，将 102 例患者分为 Hcy<10μmol/L 组（n=47）和 Hcy≥10μmol/L 组（n=55）。比较两组间 Hcy 与 BPV 及 Hcy 与 LVH 的差异。最后，分析 Hcy 与 BPV 之间、Hcy 与 LVH 之间的相关性。
结果
结果显示，两组间 Hcy 与 BPV 及 Hcy 与 LVH 均存在显著差异。Hcy 与夜间舒张压变异系数（nDBPSD）及夜间收缩压标准差（nSBP）呈正相关，相关系数分别为 0.331 和 0.303（P<0.001）。同时，Hcy 与左心室肥厚的指标室间隔厚度和左心室后壁厚度呈正相关，相关系数分别为 0.350 和 0.352（P<0.001）。
结论
Hcy 与 BPV 之间、Hcy 与 LVH 之间存在相关性。对于原发性高血压患者，还应注意血 Hcy 和 BPV。
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