Absenger Gudrun, Terzic Jasmin, Bezan Angelika
Klinische Abteilung für Onkologie, LKH-Univ. Klinikum Graz, Auenbruggerplatz 15, 8036 Graz, Austria.
Memo. 2017;10(4):224-227. doi: 10.1007/s12254-017-0373-x. Epub 2017 Dec 1.
In the past few years there have been major changes in the treatment landscape in oncology; lung cancer is affected by those changes like almost no other solid tumor. The rise of further second- and third-line tyrosine kinase inhibitors offers sequential therapy for patients with mutated non-small-cell lung cancer. Immunotherapy has found its way into clinical routine and presents us with new challenges in managing side effects, evaluating treatment response and deciding on how long we treat our patients. The treatment algorithm of lung cancer has changed in the last month and further practice-changing trials are coming up, so treating lung cancer patients shows nowadays a more challenging perspective with the possibility of subsequently applied individual therapies. This article provides a brief overview of the highlights presented at the ASCO (American Society of Clinical Oncology) annual meeting this year in Chicago.
在过去几年里,肿瘤治疗领域发生了重大变化;肺癌几乎比其他任何实体瘤都更受这些变化的影响。更多二线和三线酪氨酸激酶抑制剂的出现为非小细胞肺癌突变患者提供了序贯治疗。免疫疗法已进入临床常规治疗,在管理副作用、评估治疗反应以及决定患者的治疗时长方面给我们带来了新挑战。肺癌的治疗方案在过去一个月里发生了变化,更多改变实践的试验即将开展,因此如今治疗肺癌患者面临着更具挑战性的局面,后续可能会应用个体化治疗。本文简要概述了今年在芝加哥举行的美国临床肿瘤学会(ASCO)年会上展示的要点。