Gamrot-Wrzoł Marta, Sowa Paweł, Lisowska Grażyna, Ścierski Wojciech, Misiołek Maciej
Clinical Department of Otorhinolaryngology and Laryngological Oncology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
Biomed Res Int. 2017;2017:9195163. doi: 10.1155/2017/9195163. Epub 2017 Nov 9.
Sinonasal inverted papilloma is a relatively rare disease; however, it is prevalent enough for every ENT practitioner to encounter it several times throughout medical routines. Despite the developments in experimental and clinical medicine as well as surgical techniques, our knowledge of this disease is still inadequate. With improved imaging and better diagnostic techniques, proper diagnosis and qualification for surgical approaches leave no doubt. Although the endoscopic approach seems to be the gold standard for such condition, some cases may additionally require an external approach. Regardless of the type of surgery, postoperative management is crucial for both healing and long-term follow-up. Unfortunately, the procedures are still lacking in explicit and standardized postoperative management guidelines. Moreover, an important issue is still the need for a biomarker indicative of inverted papilloma and its malignant transformation. Several particles, within the spotlight of the researchers, have been SCCA, Ki-67, Bcl-2, Wnt proteins, and many more. Nevertheless, the topic requires further investigations.
鼻窦内翻性乳头状瘤是一种相对罕见的疾病；然而，其发病率足以让每位耳鼻喉科医生在日常医疗工作中多次遇到。尽管实验医学、临床医学以及外科技术都有所发展，但我们对这种疾病的了解仍然不足。随着成像技术的改进和诊断技术的提高，对于手术方法的正确诊断和评估已毫无疑问。虽然内镜手术似乎是这种情况的金标准，但有些病例可能还需要外部手术。无论手术类型如何，术后管理对于愈合和长期随访都至关重要。不幸的是，目前仍缺乏明确和标准化的术后管理指南。此外，一个重要问题仍然是需要一种指示内翻性乳头状瘤及其恶变的生物标志物。在研究人员的关注焦点中，有几种物质，包括鳞状细胞癌抗原（SCCA）、Ki-67、Bcl-2、Wnt蛋白等等。然而，这个话题仍需要进一步研究。
