Daglas Rothanthi, Allott Kelly, Yücel Murat, Henry Lisa P, Macneil Craig A, Hasty Melissa K, Berk Michael, Cotton Sue M
Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road, Parkville, VIC, 3052, Australia.
Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, VIC, 3052, Australia.
Int J Bipolar Disord. 2017 Dec 18;5(1):39. doi: 10.1186/s40345-017-0108-2.
The purpose of this study was to examine cognitive functioning in people following first-episode mania relative to a demographically similar healthy control group.
Forty-one patients, who had recently stabilised from a first manic episode, and twenty-one healthy controls, were compared in an extensive cognitive assessment.
First-episode mania participants had significantly lower Full-Scale IQ (FSIQ) relative to healthy controls; however, this finding could be driven by premorbid differences in intellectual functioning. There were no significant differences between groups in Verbal IQ (VIQ) and Performance IQ (PIQ). First-episode mania participants performed significantly poorer than healthy controls in processing speed, verbal learning and memory, working memory, and cognitive flexibility with medium-to-large effects. There were no group differences in other measures of cognition.
Participants following first-episode mania have poorer global intelligence than healthy controls, and have cognitive difficulties in some, but not all areas of cognitive functioning. This highlights the importance of early intervention and cognitive assessment in the early course of the disorder.
本研究的目的是对比首次发作躁狂症患者与人口统计学特征相似的健康对照组的认知功能。
对41名近期首次躁狂发作病情已稳定的患者和21名健康对照者进行了全面的认知评估并比较。
首次发作躁狂症患者的全量表智商（FSIQ）显著低于健康对照组；然而，这一发现可能是由病前智力功能差异导致的。两组在言语智商（VIQ）和操作智商（PIQ）方面无显著差异。首次发作躁狂症患者在加工速度、言语学习与记忆、工作记忆和认知灵活性方面的表现明显比健康对照组差，效应量为中到大型。在其他认知测量方面，两组无差异。
首次发作躁狂症患者的整体智力低于健康对照组，且在部分而非所有认知功能领域存在认知困难。这凸显了在该疾病早期进行早期干预和认知评估的重要性。
