Neuropsychology Section, Department of Psychiatry, University of Michigan, Ann Arbor, USA.
Am J Alzheimers Dis Other Demen. 2011 Jun;26(4):326-33. doi: 10.1177/1533317511411907. Epub 2011 Jun 1.
The aim of this study was to evaluate the short-term stability and reliability of a brief computerized cognitive battery in established dementia types.
Patients were administered the computerized battery twice with administrations approximately 2 hours apart, with intervening conventional neuropsychological tests. Patients were classified clinically, via consensus conference, as healthy controls (n = 23), mild cognitive impairment (n = 20), Alzheimer's disease (n = 52), dementia with Lewy Bodies ([DLB], n = 10), or frontotemporal dementia (n = 9).
Minimal practice effects were evident across Cog-State test administrations. Small magnitude improvements were seen across all groups on a working memory task, and healthy controls showed a mild practice effect on the accuracy of associative learning.
In established dementia, administration of the CogState tasks appears sensitive to cognitive impairment in dementia. Repeat administration also provided acceptable stability and test-retest reliability with minimal practice effects at short test-retest intervals despite intervening cognitive challenges.
本研究旨在评估一种简短的计算机化认知电池在已确诊的痴呆症类型中的短期稳定性和可靠性。
将计算机化电池两次施用于患者，两次给药间隔约 2 小时，中间穿插进行传统神经心理学测试。通过共识会议，临床将患者分类为健康对照组（n=23）、轻度认知障碍（n=20）、阿尔茨海默病（n=52）、路易体痴呆症（DLB，n=10）或额颞叶痴呆（n=9）。
在 Cog-State 测试的两次给药中，均可见最小的练习效应。在所有组中，工作记忆任务均有较小幅度的改善，而健康对照组在联想学习的准确性方面表现出轻度的练习效应。
在已确诊的痴呆症中，CogState 任务的实施对痴呆症的认知障碍敏感。尽管存在认知挑战，但在短测试-重测间隔内进行重复给药，也提供了可接受的稳定性和测试-重测可靠性，并且练习效应最小。
