Ellims P H, Van der Weyden M B, Brodie G N, Firkin B G, Whiteside M G, Faragher B S
Cancer. 1979 Dec;44(6):2140-6. doi: 10.1002/1097-0142(197912)44:6<2140::aid-cncr2820440626>3.0.co;2-w.
Three patients with drug-induced hypoplastic anemia terminating 2 to 6 years after presentation with erythroleukemia are described. All were treated for prolonged periods with androgen and corticosteroid and two of the patients showed apparent dependence on this therapy for optimal hematologic status. The leukemic phase was heralded by loss of this dependence and development of sideroblastic dyserythropoiesis with progression to bizarre erythroid hyperplasia and fatal cytopenia. The exact relationship between androgen and corticosteroid therapy and the erythroleukemia remains speculative.
本文描述了3例药物性再生障碍性贫血患者，这些患者在出现红白血病后2至6年病情终末期。所有患者均长期接受雄激素和皮质类固醇治疗，其中2例患者的血液学最佳状态明显依赖于这种治疗。白血病期的特征是这种依赖性丧失，出现铁粒幼细胞性红细胞生成异常，并进展为奇异的红系增生和致命的血细胞减少。雄激素和皮质类固醇治疗与红白血病的确切关系仍属推测。
